Drug Discovery & Development
Recent Submissions
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Development and application of omics technologies for the monitoring of personalized therapeutic protocols
(Universita degli studi di Salerno, 2022-05-05)During the 1st year the scientific activity was focused on the development of an experimental protocol aimed to evaluate the possible involvement of Sortilin (Sort), a membrane glycoprotein, in the modulation of sphingolipids ... -
Annexin A1 in pancreatic cancer progression
(Universita degli studi di Salerno, 2022-02-02)Pancreatic cancer (PC) is one of the most aggressive cancers in the world and it correlates to poor prognosis and high mortality due to late diagnosis, even if early diagnosed. Resectable PC patients have unfavorable outcome ... -
Development and Evaluation of Innovative Stationary Phases for Separation of Pharmaceuticals, Metabolites and Biocompounds
(Universita degli studi di Salerno, 2020-09-18)Biofluids are typical complex matrices representing a source of potential biomarkers, but often require high demands in sample preparation prior to analysis. With this purpose, several techniques have been developed ... -
Development of a versatile screening platform for the identification of small-molecule ligands for reader proteins of the post-translational methylation
(Universita degli studi di Salerno, 2021-06-25)Covalent Post Translational Modifications (PTMs) of histone proteins are introduced and removed by the ‘writer’ and ‘eraser’ enzymes, respectively. These modifications are recognized by highly specific binding domains, ... -
Design, synthesis and biological evaluation of small molecules able to interact with macromolecular targets involved in tumor pathology
(Universita degli studi di Salerno, 2021-05-06)Inflammation and cancer are two complex pathological processes that exploit several molecular actors. The identification of new platforms able to interfere with biological targets placed at the crossroads of these two ... -
Is the inflammasome at the crosstalk between COPD and lung cancer?
(Universita degli studi di Salerno, 2020-10-26)Background. Chronic obstructive pulmonary disease (COPD) is considered as a risk factor for lung cancer establishment. Epidemiological evidence indicate that patients with COPD have a 6.35-fold higher risk to develop lung ... -
Rational design, synthesis and in vitro evaluation of cell-active chemical probes for bromodomain-containing proteins Alessandra
(Universita degli studi di Salerno, 2021-06-25)Bromodomains (BRDs) are epigenetic readers able to selectively recognize the acetylated lysine residues on histone and non-histone proteins. Through their activity, bromodomain-containing proteins (BRDs) are involved in a ... -
Isolation, characterization and biologica! evaiuation of bioactive compounds from compiex matrices with high nutraceutica! vaiue
(Universita degli studi di Salerno, 2021-06-17)My PhD project based its main objective on the isolation, the characterization and the biological evaluation of bioactive compounds deriving from food matrices of animal and vegetable origin typical of the Mediterranean ... -
Onconutraceutics and personalized medicine: isolation, characterization, pharmacokinetics and biological evaluation of antiproliferative compounds from complex natural matrices
(Universita degli studi di Salerno, 2021-06-06)The PhD research project aims to the study of novel onconutraceuticals obtained from natural matrices for their potential use in the prevention and as valid support to the pharmacological therapies for the treatment of ... -
Effects of the isoprenoid derivative N6-benzyladenosine in cancer progression
(Universita degli studi di Salerno, 2021-05-07)N6-isopentenyladenosine (IPA) and its analogue N6-benzyladenosine (N6-BA) are modified nucleosides endowed with potent in vitro antitumor activity on different types of human cancers, including colorectal cancer (CRC) and ... -
Target-based study to identify new bioactive diterpenes
(Universita degli studi di Salerno, 2019-04-16)Target identification and mechanism of action studies of plant-derived compounds play a critical role in drug discovery. The knowledge of the bioactivity of natural compounds can lead to a number of advantages: first of ... -
Structural investigation of gp36-MPER in membrane mimicking systems
(Universita degli studi di Salerno, 2019-05-07)FIV is a lentivirus that resembles the Human Immunodeficiency Virus (HIV). The lentiviral envelope glycoproteins (gp41 in HIV and gp36 in FIV) mediate virus entry by interacting with specific receptors present at the cell ... -
Development of technological approaches based on supercritical fluids for the production of polymeric micro-nano particulate systems for wound healing
(Universita degli studi di Salerno, 2019-04-12)The PhD project titled “Development of technological approaches based on supercritical fluids for the production of polymeric micro-nano particulate systems for wound healing” aimed to develop novel formulations for topical ... -
Computational chemistry techniques for the design and the synthesis of molecules with anti-inflammatory and anti-tumor activity
(Universita degli studi di Salerno, 2019-06-18)In the last few years, computational chemistry has played an important role in disclosing novel compounds with relevant biological activity. Inflammation and cancer processes have been recently linked, and the identification ... -
Functional Characterization of Candida albicans Hst3p histone deacetylase
(Universita degli studi di Salerno, 2019-05-07)The unicellular eukaryotic organism Candida albicans is one of the most important fungi in medicine, used as experimental model to study fungal pathologies and the underlying biology of dimorphic fungi. This fungus is a ... -
Technologies for the development of health products based on up-cycling of agro-food by-products
(Universita degli studi di Salerno, 2019-04-12)The agro-industrial processing produces large volumes of wastes and by-products. In recent years, wastes and by-products have attracted attention as an excellent renewable source of active compounds with beneficial effects ... -
The Winnie-APCmin as an innovative tool to investigate the axis between inflammation and colorectal cancer
(Universita degli studi di Salerno, 2019-05-07)During these last three yeas of PhD we aimed to create a new murine model of spontaneous inflammatory-induced colorectal cancer a combining the genetic susceptibility of the APCMin model and the chronic intestinal inflammation ... -
Design and synthesis of bioactive small molecules by traditional and innovative methods
(Universita degli studi di Salerno, 2018-03-28)My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ... -
Role of CD73 - A2A/A2B receptors axis in cancer
(Universita degli studi di Salerno, 2018-04-05)The adenosinergic pathway plays a critical role in cancer development and progression, as well as in drug resistance to chemotherapy and/or targeted-therapy. The goal of this PhD thesis was to investigate and fully ... -
PGI products of Campania region: chemical and biological investigation of edible parts and by-products as potential sources of functional ingredients for herbal, nutraceutical and cosmetic formulations.
(Universita degli studi di Salerno, 2018-05-05)This project is addressed to the definition of the chemical profile of selected PGI products of Campania region and related byproducts to highlight the presence of phytochemicals with health benefits. The species studied ...
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