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Design and synthesis of new polycyclic compounds with potential anticancer activity
(Universita degli studi di Salerno, 2011-02-21)
p53 is best known as a tumor suppressor that transcriptionally regulates, in response to cellular stresses such as DNA damage or oncogene activation, the expression of various target genes that mediate cell-cycle arrest, ...
Ruolo della proteina BAG3 nel microambiente tumorale
(Universita degli studi di Salerno, 2012-02-27)
Recenti studi hanno dimostrato che il microambiente tumorale subisce numerosi cambiamenti nel corso dello sviluppo del tumore e influenza l’evoluzione e la progressione del cancro. L'ambiente ipossico del tumore stimola ...
Novel Insights into the Biological Effects of the Isoprenoid Derivative N6-Isopentenyladenosine: Involvement of the Metabolic Sensor Ampk in Angiogenesis Inhibition
(Universita degli studi di Salerno, 2014-03-19)
N6-isopentenyladenosine (iPA) is a modified adenosine characterized by an isopentenyl chain derived by dimethylallyl pyrophosphate (DMAPP), an intermediate of the metabolic pathway of mevalonate, that is known to be ...
Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(Universita degli studi di Salerno, 2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...
Studio di metaboliti secondari provenienti da specie vegetali che agiscono sul SNC
(Universita degli studi di Salerno, 2011-01-27)
L’utilizzo delle piante medicinali nasce con l’uomo. Lo studio delle
basi scientifiche a supporto del loro utilizzo si è sviluppato e continua a
svilupparsi da poco più di un secolo. Lo scopo di questo lavoro di dottorato ...
Sequence analysis in bioinformatics: methodological and practical aspects
(Universita degli studi di Salerno, 2013-04-02)
My PhD research activities has focused on the development of new
computational methods for biological sequence analyses.
To overcome an intrinsic problem to protein sequence analysis, whose aim was
to infer homologies ...
The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity
(Universita degli studi di Salerno, 2014-05-21)
The thesis entitled “The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity" is divided into three chapters.
The title of the thesis clearly reflects the ...
Biophysical investigation of biomolecules in bio-membrane models
(Universita degli studi di Salerno, 2012-05-30)
Many drugs are available for the treatment of systemic or superficial mycoses,
but only a limited number of them are effective antifungal drugs, devoid of
toxic and undesirable side effects. Therefore there remains an ...
Le complicanze cardiovascolari nel diabete mellito: studio delle basi molecolari
(Universita degli studi di Salerno, 2013-02-13)
Diabetes is characterized by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis.
The assumption underlying current clinical treatment is that lowering the level of ...
Trafficking from the Endoplasmic Reticulum to the Golgi complex and gene expression profiling during the cell stress
(Universita degli studi di Salerno, 2012-02-01)
The elucidation of the molecular mechanisms regulating the export from the Endoplasmic Reticulum (ER) and the transport to post-ER compartments of secretory proteins represents the basic aim of the present PhD project.
To ...