Chimica
Recent Submissions
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Exploring batch and flow catalytic reactions as valuable tools for safer and greener synthesis of APIs and their fluorine intermediates
(Universita degli studi di Salerno, 2022-06-06)Il gruppo trifluorometiltio (SCF3) assume un ruolo chiave nel campo della scoperta di farmaci grazie alle sue proprietà uniche. Il forte carattere elettron-attratore e lipofilo rende vantaggiosa la sua incorporazione ... -
New metal catalysts for Ring-Opening Polymerization of cyclic esters
(Universita degli studi di Salerno, 2022-05-28)I problemi ambientali ed economici legati ai polimeri derivanti da fonti petrolchimiche hanno spinto la ricerca accademica verso lo sviluppo di alternative green e degradabili rispetto alle plastiche convenzionali. I ... -
Idenffication of potyphenols in grape pomuce and newsynthetíc approaches to 2'3' diaryl-2,3- dihydribioro?uronr, uríIuí oitíve ingredients agaínst degenerutíve diseuses
(Universita degli studi di Salerno, 2022-02-10)The PhD project is divided in two main studies, the first concerning in the identification of polyphenols in Grape Pomace and the second in developing new synthetic approaches to 2,3-disubstituted-2,3- dihydlobenzofurans. The ... -
Synthesis and cascade reactions of new heterocyclic compounds
(Universita degli studi di Salerno, 2022-02-28)More than 70% of modern organic chemistry is focused on the synthesis and application of new heterocyclic compounds in many different areas, from pharmaceuticals to agrochemicals, antioxidants or dyes. Heterocyclic ... -
Copolymerization of olefins with polar monomers by transition metal catalysts
(Universita degli studi di Salerno, 2022-06-13)The investigation into copolymerizing olefins by Ni(Il) complexes bearing pyridylimine ligands was achieved in this study. The complexes, in the presence of a proper activating agent, were found to generate active catalysts ... -
A computational approach to investigate the interactions between potential pharmacological chaperones and GALT enzyme
(Universita degli studi di Salerno, 2023-03-13)Classic galactosemia is an inborn error of metabolism associated with mutations that impair the activity and the stability of the dimeric enzyme galactose-1-phosphate uridylyltransferase (GALT), which catalyzes the ... -
Molecular Properties Via Induced Current Densities
(Universita degli studi di Salerno, 2024-02-22)The PhD thesis written by Francesco F. Summa on Molecular Properties via Induced Current Densities is a careful report of a highly qualified and innovative research. Sixteen peer-reviewed publications on renowned journals ... -
Sustainable approaches for the synthesis and the chemical degradation of polyesters
(Universita degli studi di Salerno, 2023-03-03)Petrochemical-based plastics have a significant impact on modern society, as underlined by their high production and countless applications. Indeed, the production of plastics has increased over the past 50 years, reaching ... -
Towards new catalysts for polymerization of ethylene and copolymerization of ethylene with carbon monoxide: a rational design approach
(Universita degli studi di Salerno, 2023-03-10)The steric and the electronic environment are the fundamental parameters that define the catalytic properties of any active site. For late transition metal catalysts, they determine polymer molecular weight and branching ... -
Asymmetric synthesis of Heterocyclic Compounds through cascade Carbon-Carbon and Carbon-Heteroatom bond forming processes
(Universita degli studi di Salerno, 2023-06-06)The aim of my PhD thesis was focused on the asymmetric synthesis of new heterocyclic compounds using cascade and tandem processes involving the formation of new binding Carbon-Carbon and Carbon- Heteroatom. Heterocyclic ... -
Isolation and characterization of lignins from Wheat straw and cardoon biomasses
(Universita degli studi di Salerno, 2023-03-13)The progressive reduction in the availability of oil resources, the unstoppable increase in their costs and the growing need for efficient environmental protection, imply an urgent development of new technologies for the ... -
Molecular bases of gluten toxicity and Relationship with the enzyme Transglutaminase in celiac disease
(Universita degli studi di Salerno, 2022-06-17)Celiac disease (CD) is a life-long gluten-sensitive immune-mediated disorder that primarily affects the small intestine of genetically susceptible individuals worldwide. Type 2 transglutaminase (TG2) has two crucial roles ... -
Synthesis of Eco-Friendly Additives for Sustainable Tanning Processes
(Universita degli studi di Salerno, 2022-06-08)Sustainability is a global level challenge for tanning industry whose production is based on Cr(III) salts for more than 90%, negatively impacting both biotic and abiotic factors in an ecosystem. Societal challenges ... -
Complexes of coinage metals stabilized by N-heterocyclic carbenes: catalytic and biological activities
(Universita degli studi di Salerno, 2022-05-30)Since the synthesis, the isolation, and the characterization of the first stable N-heterocyclic carbene (NHC) in 1991 by Arduengo and collaborators, this class of ligands has attracted the attention of researchers for ... -
Synthesis of New Naphthol-Based Macrocycles for Supramolecular Applications
(Universita degli studi di Salerno, 2022-01-21)Nature has always inspired supramolecular chemists who, with the aim to mimic the structural features of the natural receptors, have designed artificial systems with amazing functions and properties. Therefore, in the ... -
“Analysis of biochemical pathways involved into protective effects of bioactive compounds: focus on Omega-3 Polyunsaturated Fatty Acids”
(Universita degli studi di Salerno, 2022-06-06)Dietary fat sources differently affect cellular metabolism, with different effects on metabolic disease risks. In the present PhD thesis, it was evaluated the effect of Omega-3 Polyunsaturated Fatty Acids (Omega-3 PUFAs), ... -
Monitoraggio e conservazione dei beni culturali Lapidei:indagini diagnostiche mediante tecniche Di superficie e metodologie innovative per Interventi di manutenzione sostenibile
(Universita degli studi di Salerno, 2022-06-05)In recent decades, the historical and artistic heritage has undergone a greater degradation than in the past, in relation to the synergic action of atmospheric pollution, climate changes, and biological contamination. ... -
New insights on the ecology of underground ecosystems toward a sustainable management strategy
(Universita degli studi di Salerno, 2022-03-08)Underground cavities represent some of the less explored places on the planet. In fact, excluding the known carbonate dissolution/precipitation processes, leading to the formation of holes in the host rock, as well as ... -
The Role of ABCC6 Transporter in the Purinergic System: from Oncology to Regenerative Medicine
(Universita degli studi di Salerno, 2022-06-20)ABCC6 is a member of ATP-binding cassette family of transporters, a class of membrane transporters sharing a common structural organization. Mutations in ABCC6 are associated with Pseudoxantoma elasticum (PXE) and with ... -
Capsicum annuum L.cv senise and solanum aethiopicum L.cv Rotonda: phytochemical profile and cell-based assays
(Universita degli studi di Salerno, 2021-05-10)Natural products rich in health-promoting compounds could represent new potential therapy strategy in many diseases. In the present study we focus our attention on Capsicum annuum L. cv Senise and Solanum aethiopicum ...
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