Sfoglia Area Scienze mediche per Titolo
Items 54-73 di 138
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Effects of the isoprenoid derivative N6-benzyladenosine in cancer progression
(Universita degli studi di Salerno, 2021-05-07)N6-isopentenyladenosine (IPA) and its analogue N6-benzyladenosine (N6-BA) are modified nucleosides endowed with potent in vitro antitumor activity on different types of human cancers, including colorectal cancer (CRC) and ... -
Effetti a lungo termine dell’applicazione di ammendante compostato sulla qualità chimica e biologica di suoli agrari
(Universita degli studi di Salerno, 2014-10-02)Il compost è un fertilizzante ottenuto dalla decomposizione biologica di rifiuti organici in condizioni controllate. Il processo di decomposizione biologica porta ad una parziale mineralizzazione dei composti organici più ... -
Effetti degli acidi grassi polinsanturi sui processi di sviluppo e progressione tumorale
(Universita degli studi di Salerno, 2015-03-16)Molteplici analisi in vitro e in vivo hanno evidenziato la capacità di diversi fattori nutrizionali di influenzare i processi di carcinogenesi e di progressione tumorale. Gli acidi grassi polinsaturi (PUFA) della serie ... -
Effetto selettivo di sieri umani dislipidemici e degli acidi grassi poliinsaturi sull'espressione genica
(Universita degli studi di Salerno, 2011-02-21)Serum profile, in physiological or pathological conditions, results from the whole effect of both nutritional intake and endogenous metabolism and is commonly used as diagnostic tool. Moreover individual serum components ... -
Espressione genica indotta dall'ormone somatotropo nei monociti di bambini sani e con deficit di GH
(Universita degli studi di Salerno, 2020-07-13)Somatotropic hormone (GH) has transcriptional effects on the cells of many organs, directly by activating its receptor (GHR) or indirectly through induction of IGF-1 or other mediators. The presence of GHR in almost all ... -
Essential Infantile Esotropia with Inferior Oblique hyperfunction and Lateral Recti pseudoparalysis: long term follow-up of 6 muscles approach
(Universita degli studi di Salerno, 2016-04-21)AIM: Analysis of long-term follow-up (3 months, 2 years, 5 years and 10 years) in Infantile Esotropia patients (IE), after a 6 muscles approach. METHODS: A 6 muscles approach in IE has been evaluated in patients with ... -
Exploring the chemical diversity in marine organisms: new molecules for pharmaceutical applications
(Universita degli studi di Salerno, 2012-02-23)It is increasingly recognized that the oceans preserve a huge number of natural products and novel chemical entities, with biological activities that may be useful in the quest for finding drugs with greater efficacy and ... -
Functional and metabolic brain correlates in hearing loss and rehabilitation
(Universita degli studi di Salerno, 2021-04-19)The human auditory system serves the role of extracting information from objects in the environment engaging in analyses of the auditory world so that the listener can accomplish the goal of learning and communication. ... -
Functional Characterization of Candida albicans Hst3p histone deacetylase
(Universita degli studi di Salerno, 2019-05-07)The unicellular eukaryotic organism Candida albicans is one of the most important fungi in medicine, used as experimental model to study fungal pathologies and the underlying biology of dimorphic fungi. This fungus is a ... -
“Functional MRI Study of Human Gustatory Cortex: Technological Advancements and Applications to Basic and Clinical Neurosciences”
(Universita degli studi di Salerno, 2019-03-08)The purpose of brain plasticity is generating adaptive behaviours while predicting, interpreting, and responding to more and more complex tasks. Some of the most riveting questions in neuroscience revolve around the ... -
Hairy root culture as source of novel plant-derived active compounds with applications in cosmetics
(Universita degli studi di Salerno, 2015-04-22)Hyperpigmentation is the process by which an excess of melanin is produced by the skin. Typically, hyperpigmentation occurs as a result of stress, damage or prolonged inflammation of the skin. The most common cause is sun ... -
Identification of new genetic alterations and potential biomarkers in papillary thyroid carcinoma
(Universita degli studi di Salerno, 2016-05-24)Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignant neoplasia. Oncogene activation occurs in more than 70% of the cases. BRAF mutations occur in about 40% of PTCs, whereas RET rearrangements ... -
Il sistema adenosinico: principali targets molecolari ad attività anti-tumorale
(Universita degli studi di Salerno, 2012-02-27)L’Adenosina (Ado) è una molecola segnale di origine purinica che esplica le sue funzioni metaboliche mediante quattro recettori metabotropici (A1, A2A, A2B, A3). L’Ado è un autacoide ad attività pleiotropica, che regola ... -
In vitro and in cell functional proteomics on natural compounds
(Universita degli studi di Salerno, 2014-04-24)Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification ... -
In vitro and in vivo study of cannabinoids as modulators of Wnt/β-catenin pathway in human colorectal cancer
(Universita degli studi di Salerno, 2017-03-23)Colorectal cancer (CRC) is the second most common cause of cancer death. Molecular events in CRC has been extensively studied and several data suggest that Wnt/β-catenin signaling deregulation play a pivotal role in ... -
In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(Universita degli studi di Salerno, 2017-03-31)Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive ... -
L'influenza del rame sull'espressione e l'attività del fattore gastrointestinaleTFF1
(Universita degli studi di Salerno, 2015-04-23)Il tratto gastrointestinale rappresenta una interfaccia tra il corpo e l’ambiente esterno. È dotato di sofisticati meccanismi che ne regolano la funzionalità e attua efficaci strategie per la sua protezione affidandosi a ... -
Integrated metabolomics approaches for berry fruit used in nutraceutical formulations
(Universita degli studi di Salerno, 2016-04-13)The species under investigation during these three years of PhD course were: Fragaria ananassa, Fragaria vesca, Morus alba, Morus nigra and Myrtus communis. All these species are characterized by the production of small ... -
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform
(Universita degli studi di Salerno, 2020-10-24)The identification of natural products (NPs) target proteins is pivotal to understand their mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years, affinity chromatogra ... -
Is the inflammasome at the crosstalk between COPD and lung cancer?
(Universita degli studi di Salerno, 2020-10-26)Background. Chronic obstructive pulmonary disease (COPD) is considered as a risk factor for lung cancer establishment. Epidemiological evidence indicate that patients with COPD have a 6.35-fold higher risk to develop lung ...