Sfoglia Area Scienze mediche per Titolo
Items 64-83 di 138
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Hairy root culture as source of novel plant-derived active compounds with applications in cosmetics
(Universita degli studi di Salerno, 2015-04-22)Hyperpigmentation is the process by which an excess of melanin is produced by the skin. Typically, hyperpigmentation occurs as a result of stress, damage or prolonged inflammation of the skin. The most common cause is sun ... -
Identification of new genetic alterations and potential biomarkers in papillary thyroid carcinoma
(Universita degli studi di Salerno, 2016-05-24)Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignant neoplasia. Oncogene activation occurs in more than 70% of the cases. BRAF mutations occur in about 40% of PTCs, whereas RET rearrangements ... -
Il sistema adenosinico: principali targets molecolari ad attività anti-tumorale
(Universita degli studi di Salerno, 2012-02-27)L’Adenosina (Ado) è una molecola segnale di origine purinica che esplica le sue funzioni metaboliche mediante quattro recettori metabotropici (A1, A2A, A2B, A3). L’Ado è un autacoide ad attività pleiotropica, che regola ... -
In vitro and in cell functional proteomics on natural compounds
(Universita degli studi di Salerno, 2014-04-24)Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification ... -
In vitro and in vivo study of cannabinoids as modulators of Wnt/β-catenin pathway in human colorectal cancer
(Universita degli studi di Salerno, 2017-03-23)Colorectal cancer (CRC) is the second most common cause of cancer death. Molecular events in CRC has been extensively studied and several data suggest that Wnt/β-catenin signaling deregulation play a pivotal role in ... -
In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(Universita degli studi di Salerno, 2017-03-31)Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive ... -
L'influenza del rame sull'espressione e l'attività del fattore gastrointestinaleTFF1
(Universita degli studi di Salerno, 2015-04-23)Il tratto gastrointestinale rappresenta una interfaccia tra il corpo e l’ambiente esterno. È dotato di sofisticati meccanismi che ne regolano la funzionalità e attua efficaci strategie per la sua protezione affidandosi a ... -
Integrated metabolomics approaches for berry fruit used in nutraceutical formulations
(Universita degli studi di Salerno, 2016-04-13)The species under investigation during these three years of PhD course were: Fragaria ananassa, Fragaria vesca, Morus alba, Morus nigra and Myrtus communis. All these species are characterized by the production of small ... -
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform
(Universita degli studi di Salerno, 2020-10-24)The identification of natural products (NPs) target proteins is pivotal to understand their mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years, affinity chromatogra ... -
Is the inflammasome at the crosstalk between COPD and lung cancer?
(Universita degli studi di Salerno, 2020-10-26)Background. Chronic obstructive pulmonary disease (COPD) is considered as a risk factor for lung cancer establishment. Epidemiological evidence indicate that patients with COPD have a 6.35-fold higher risk to develop lung ... -
Isolation, characterization and biologica! evaiuation of bioactive compounds from compiex matrices with high nutraceutica! vaiue
(Universita degli studi di Salerno, 2021-06-17)My PhD project based its main objective on the isolation, the characterization and the biological evaluation of bioactive compounds deriving from food matrices of animal and vegetable origin typical of the Mediterranean ... -
Le complicanze cardiovascolari nel diabete mellito: studio delle basi molecolari
(Universita degli studi di Salerno, 2013-02-13)Diabetes is characterized by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis. The assumption underlying current clinical treatment is that lowering the level of ... -
Metabolic control of FoxP3 expression in human regulatory T cells
(Universita degli studi di Salerno, 2017-05-30)Regulatory CD4+CD25+ T (Treg) cells play a central role in the maintenance of immune self-tolerance and homeostasis. Although Treg cells operate through multiple mechanisms, it appears that the expression of the transcription ... -
Molecular basis of cardiomiopathy
(Universita degli studi di Salerno, 2018-04-05)The normal heart rhythm is guaranteed by an important intercellular junctions system, named Gap Junction (GJs). Each GJs consists of two units called connexons formed by six specific trans-membrane proteins named connexins ... -
Neurodegeneration in Chronic Kidney Disease: role of neuroinflammation and uremic toxins
(Universita degli studi di Salerno, 2017-03-28)Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ... -
Neuroimmune regulation of JCV by immune mediators in glial cells
(Universita degli studi di Salerno, 2015-04-23)The human polyomavirus JC (JCV) is a small DNA virus responsible for the initiation of progressive multifocal leukoencephalopathy (PML), an often lethal disease of the brain characterized by lytic infection of oligodendrocytes ... -
New Encapsulation Technologies for The Development of in Situ Gelling Micro- Nano Particulate Systems for The Wound Healing
(Universita degli studi di Salerno, 2016-03-16)The Ph.D project titled “New Encapsulation technologies for the development of in situ gelling micro-nano particulate systems for the wound healing” aimed to develop novel topical formulations by innovative technologies, ... -
NMR study of protein-ligand interaction
(Universita degli studi di Salerno, 2015-03-11)My PhD project was focused on the study of protein-ligands interactions using different NMR techniques. NMR has a long history in drug discovery and hit-to-lead optimization. Compared to many other biophysical techniques, ... -
NMR-based metabolomic analysis of biological fluids to monitor relevant unsolved diseases
(Universita degli studi di Salerno, 2017-03-30)Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle, environment, stimuli and genetic ... -
Novel Insights into the Biological Effects of the Isoprenoid Derivative N6-Isopentenyladenosine: Involvement of the Metabolic Sensor Ampk in Angiogenesis Inhibition
(Universita degli studi di Salerno, 2014-03-19)N6-isopentenyladenosine (iPA) is a modified adenosine characterized by an isopentenyl chain derived by dimethylallyl pyrophosphate (DMAPP), an intermediate of the metabolic pathway of mevalonate, that is known to be ...