Sfoglia Area Scienze mediche per Titolo
Items 78-97 di 138
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Neurodegeneration in Chronic Kidney Disease: role of neuroinflammation and uremic toxins
(Universita degli studi di Salerno, 2017-03-28)Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ... -
Neuroimmune regulation of JCV by immune mediators in glial cells
(Universita degli studi di Salerno, 2015-04-23)The human polyomavirus JC (JCV) is a small DNA virus responsible for the initiation of progressive multifocal leukoencephalopathy (PML), an often lethal disease of the brain characterized by lytic infection of oligodendrocytes ... -
New Encapsulation Technologies for The Development of in Situ Gelling Micro- Nano Particulate Systems for The Wound Healing
(Universita degli studi di Salerno, 2016-03-16)The Ph.D project titled “New Encapsulation technologies for the development of in situ gelling micro-nano particulate systems for the wound healing” aimed to develop novel topical formulations by innovative technologies, ... -
NMR study of protein-ligand interaction
(Universita degli studi di Salerno, 2015-03-11)My PhD project was focused on the study of protein-ligands interactions using different NMR techniques. NMR has a long history in drug discovery and hit-to-lead optimization. Compared to many other biophysical techniques, ... -
NMR-based metabolomic analysis of biological fluids to monitor relevant unsolved diseases
(Universita degli studi di Salerno, 2017-03-30)Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle, environment, stimuli and genetic ... -
Novel Insights into the Biological Effects of the Isoprenoid Derivative N6-Isopentenyladenosine: Involvement of the Metabolic Sensor Ampk in Angiogenesis Inhibition
(Universita degli studi di Salerno, 2014-03-19)N6-isopentenyladenosine (iPA) is a modified adenosine characterized by an isopentenyl chain derived by dimethylallyl pyrophosphate (DMAPP), an intermediate of the metabolic pathway of mevalonate, that is known to be ... -
Novel respirable powder formulation: design, aerosolization and permeation studies through pulmonary epithelial cell line and mucus models.
(Universita degli studi di Salerno, 2015-03-18)Direct administration of drugs to the lungs has been used for millennia as a major treatment for a number of diseases. Origin of the inhalation therapies can be found 2000 B.C in India, where people were used to smoke ... -
Nuove prospettive terapeutiche del glioma: N6-isopenteniladenosina ed SR141716
(Universita degli studi di Salerno, 2016-03-04)Glioma is a fatal disease characterized by uncontrolled cellular proliferation and it is the most common primary brain malignancy in adults. Despite years of research, malignant glioma remains one of the most aggressive ... -
Nuove strategie per l'identificazione di molecole ad attività antifungina
(Universita degli studi di Salerno, 2013-01-30)Con l’incremento del numero di persone affette da sindrome da immunodeficienza acquisita (AIDS), dell’uso di terapie immunosoppressive e del numero di pazienti affetti da varie forme di cancro e, dunque, fortemente debilitati ... -
Onconutraceutics and personalized medicine: isolation, characterization, pharmacokinetics and biological evaluation of antiproliferative compounds from complex natural matrices
(Universita degli studi di Salerno, 2021-06-06)The PhD research project aims to the study of novel onconutraceuticals obtained from natural matrices for their potential use in the prevention and as valid support to the pharmacological therapies for the treatment of ... -
Opportunità e rischi della longevità. Aspettative presenti e future dal punto di vista epidemiologico, ecologico, medico e sociale, soprattutto sulla base dell’esperienza dei medici
(Universita degli studi di Salerno, 2021-06-15)Longevity is considered one of the greatest achievements of modern society. "Staying young forever" seems to be the new trend: Downgrading (i.e. being younger today than at the same age in the past) shows that there are ... -
p53 regulates Mevalonate Metabolic pathway
(Universita degli studi di Salerno, 2014-03-14)The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced ... -
Parodontite e carcinoma del colon-retto: la possibile associazione genetica e patogenetica
(Universita degli studi di Salerno, 2021-04-29)Base di partenza scientifica e razionale: Il carcinoma del colon-retto (CRC) è una neoplasia maligna molto comune, caratterizzata da un’incidenza stimata intorno al 9-10% ed una mortalità del circa 8-9% (700.000 morti/anno). La ... -
La Pentraxina 3: un potenziale marcatore di danno endoteliale nell’ipertensione arteriosa
(Universita degli studi di Salerno, 2016-04-26)Background - The pentraxin 3 (PTX3) is a protein of the acute phase of inflammation which represents the prototype of the long pentraxins. In the last years, numerous studies have correlated the elevated plasma levels ... -
PGI products of Campania region: chemical and biological investigation of edible parts and by-products as potential sources of functional ingredients for herbal, nutraceutical and cosmetic formulations.
(Universita degli studi di Salerno, 2018-05-05)This project is addressed to the definition of the chemical profile of selected PGI products of Campania region and related byproducts to highlight the presence of phytochemicals with health benefits. The species studied ... -
Physico-chemical characterization of DNA G-quadruplexes and their interaction with proteins and potential anticancer agents
(Universita degli studi di Salerno, 2011-10-06)Negli ultimi anni è stato dimostrato che sequenze di DNA (o RNA) ricche in guanine sono in grado di formare una nuova classe di strutture: le quadruple eliche. Importante e' la presenza di quadruple eliche in regioni ... -
Progettazione di un biosensore ottico per la determinazione atmosferica del benzene
(Universita degli studi di Salerno, 2016-04-15)In recent years, environmental pollution, particularly air pollution, is a subject of great scientific and public interests. The reason is due to the strong impact on human health. Air pollution is due to the placing in ... -
Progettazione, sintesi e valutazione dell'attività biologica di nuovi carbazoli
(Universita degli studi di Salerno, 2011-02-23)Il presente lavoro di tesi è stato svolto presso il laboratorio di Fitofarmacia del Dipartimento di Scienze Farmaceutiche dell’Università della Calabria e presso il Laboratorio di Farmacognosia dell’Università Paris Descartes ... -
Proteomic profiles of cultured cells stimulated with VEGFs dimers and search for natural compounds angiogenesis inhibitors
(Universita degli studi di Salerno, 2013-06-06)Some members of the vascular endothelial growth factor (VEGF) family, such as VEGF and PlGF, and related receptors (KDR and Flt-1) play a key role in the modulation of angiogenesis, both physiological and pathological. For ... -
Rational design, synthesis and in vitro evaluation of cell-active chemical probes for bromodomain-containing proteins Alessandra
(Universita degli studi di Salerno, 2021-06-25)Bromodomains (BRDs) are epigenetic readers able to selectively recognize the acetylated lysine residues on histone and non-histone proteins. Through their activity, bromodomain-containing proteins (BRDs) are involved in a ...