Sfoglia Area Scienze mediche per Titolo
Items 87-106 di 138
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Onconutraceutics and personalized medicine: isolation, characterization, pharmacokinetics and biological evaluation of antiproliferative compounds from complex natural matrices
(Universita degli studi di Salerno, 2021-06-06)The PhD research project aims to the study of novel onconutraceuticals obtained from natural matrices for their potential use in the prevention and as valid support to the pharmacological therapies for the treatment of ... -
Opportunità e rischi della longevità. Aspettative presenti e future dal punto di vista epidemiologico, ecologico, medico e sociale, soprattutto sulla base dell’esperienza dei medici
(Universita degli studi di Salerno, 2021-06-15)Longevity is considered one of the greatest achievements of modern society. "Staying young forever" seems to be the new trend: Downgrading (i.e. being younger today than at the same age in the past) shows that there are ... -
p53 regulates Mevalonate Metabolic pathway
(Universita degli studi di Salerno, 2014-03-14)The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced ... -
Parodontite e carcinoma del colon-retto: la possibile associazione genetica e patogenetica
(Universita degli studi di Salerno, 2021-04-29)Base di partenza scientifica e razionale: Il carcinoma del colon-retto (CRC) è una neoplasia maligna molto comune, caratterizzata da un’incidenza stimata intorno al 9-10% ed una mortalità del circa 8-9% (700.000 morti/anno). La ... -
La Pentraxina 3: un potenziale marcatore di danno endoteliale nell’ipertensione arteriosa
(Universita degli studi di Salerno, 2016-04-26)Background - The pentraxin 3 (PTX3) is a protein of the acute phase of inflammation which represents the prototype of the long pentraxins. In the last years, numerous studies have correlated the elevated plasma levels ... -
PGI products of Campania region: chemical and biological investigation of edible parts and by-products as potential sources of functional ingredients for herbal, nutraceutical and cosmetic formulations.
(Universita degli studi di Salerno, 2018-05-05)This project is addressed to the definition of the chemical profile of selected PGI products of Campania region and related byproducts to highlight the presence of phytochemicals with health benefits. The species studied ... -
Physico-chemical characterization of DNA G-quadruplexes and their interaction with proteins and potential anticancer agents
(Universita degli studi di Salerno, 2011-10-06)Negli ultimi anni è stato dimostrato che sequenze di DNA (o RNA) ricche in guanine sono in grado di formare una nuova classe di strutture: le quadruple eliche. Importante e' la presenza di quadruple eliche in regioni ... -
Progettazione di un biosensore ottico per la determinazione atmosferica del benzene
(Universita degli studi di Salerno, 2016-04-15)In recent years, environmental pollution, particularly air pollution, is a subject of great scientific and public interests. The reason is due to the strong impact on human health. Air pollution is due to the placing in ... -
Progettazione, sintesi e valutazione dell'attività biologica di nuovi carbazoli
(Universita degli studi di Salerno, 2011-02-23)Il presente lavoro di tesi è stato svolto presso il laboratorio di Fitofarmacia del Dipartimento di Scienze Farmaceutiche dell’Università della Calabria e presso il Laboratorio di Farmacognosia dell’Università Paris Descartes ... -
Proteomic profiles of cultured cells stimulated with VEGFs dimers and search for natural compounds angiogenesis inhibitors
(Universita degli studi di Salerno, 2013-06-06)Some members of the vascular endothelial growth factor (VEGF) family, such as VEGF and PlGF, and related receptors (KDR and Flt-1) play a key role in the modulation of angiogenesis, both physiological and pathological. For ... -
Rational design, synthesis and in vitro evaluation of cell-active chemical probes for bromodomain-containing proteins Alessandra
(Universita degli studi di Salerno, 2021-06-25)Bromodomains (BRDs) are epigenetic readers able to selectively recognize the acetylated lysine residues on histone and non-histone proteins. Through their activity, bromodomain-containing proteins (BRDs) are involved in a ... -
Regolazione delle funzioni del recettore dell' urochinasi
(Universita degli studi di Salerno, 2015-03-18)Il recettore per l'attivatore di tipo urochinasico del plasminogeno (uPAR), è un recettore ad áncora GPI presente sulla superficie della cellula; esso è coinvolto nei processi di migrazione cellulare e di invasione tissutale. ... -
Regolazione epigenetica dell’espressione del fattore peptidico gastrointestinale TFF1
(Universita degli studi di Salerno, 2016-04-19)TFF1 is a protein expressed in the gastrointestinal tract, belonging to the trefoil folding factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a cloverleaf disulfide ... -
Regolazione post-trascrizionale dell’espressione del recettore dell’urochinasi
(Universita degli studi di Salerno, 2016-12-14)The urokinase type plasminogen activator (uPAR) is a three domain GPI-anchored cell surface receptor. uPAR expression is strongly up-regulated and represents a negative prognostic factor in various tumors, including ... -
Rischio clinico, gestione del rischio e sue implicazioni. Un aspetto della medicina traslazionale
(Universita degli studi di Salerno, 2017-06-05)This thesis is based on the awareness that prevention in the ethical and vocational training of health workers is extremely important, above all the one concerned with the clinical risk as well as a competent and intelligent ... -
Role of Annexin A1 in tumor progression
(Universita degli studi di Salerno, 2016-10-06)Annexin 1 (ANXA1) is a multifunctional protein of 37 kDa, and represents the first characterized member of the annexin superfamily, so called since their main property is to bind (i.e. to annex) cell membranes in Ca2+-dependent ... -
Role of CD73 - A2A/A2B receptors axis in cancer
(Universita degli studi di Salerno, 2018-04-05)The adenosinergic pathway plays a critical role in cancer development and progression, as well as in drug resistance to chemotherapy and/or targeted-therapy. The goal of this PhD thesis was to investigate and fully ... -
Role of TFF1 in tumor progression
(Universita degli studi di Salerno, 2017-03-31)Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ... -
Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis
(Universita degli studi di Salerno, 2017-03-28)Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as ... -
Role of vitamin D in the modulation of chronic bowel inflammation and in the genesis of bone mass loss in patients with inflammatory bowel diseases
(Universita degli studi di Salerno, 2020-07-09)Background: Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory disorder of the gastrointestinal tract consisting two principal categories, ulcerative colitis (UC) and Crohn’s disease (CD). Bone ...