Sfoglia Area Scienze mediche per Titolo
Items 125-138 di 138
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Target-based study to identify new bioactive diterpenes
(Universita degli studi di Salerno, 2019-04-16)Target identification and mechanism of action studies of plant-derived compounds play a critical role in drug discovery. The knowledge of the bioactivity of natural compounds can lead to a number of advantages: first of ... -
Techniques of proteomic analysis as tools for studies in biomedical field
(Universita degli studi di Salerno, 2017-03-24)It is known that prenatal exposure to pollutants and particularly heavy metals can have long term damaging consequences on infants, due to their accumulation in-body. Since the 1990s, ten million tonnes of waste have been ... -
Technologies for the development of health products based on up-cycling of agro-food by-products
(Universita degli studi di Salerno, 2019-04-12)The agro-industrial processing produces large volumes of wastes and by-products. In recent years, wastes and by-products have attracted attention as an excellent renewable source of active compounds with beneficial effects ... -
The Winnie-APCmin as an innovative tool to investigate the axis between inflammation and colorectal cancer
(Universita degli studi di Salerno, 2019-05-07)During these last three yeas of PhD we aimed to create a new murine model of spontaneous inflammatory-induced colorectal cancer a combining the genetic susceptibility of the APCMin model and the chronic intestinal inflammation ... -
Trafficking from the Endoplasmic Reticulum to the Golgi complex and gene expression profiling during the cell stress
(Universita degli studi di Salerno, 2012-02-01)The elucidation of the molecular mechanisms regulating the export from the Endoplasmic Reticulum (ER) and the transport to post-ER compartments of secretory proteins represents the basic aim of the present PhD project. To ... -
The transcription factor Prep1 regulates adipose tissue functions
(Universita degli studi di Salerno, 2014-03-21)Adipose tissue is crucial for maintaining energy and metabolic homeostasis and its functionality is closely related to the adipocytes differentiation state. Adipogenesis is regulated by several transcription factors. Prep1 ... -
Transcriptional regulation of biosynthetic genes of the plant MEP-derived pathway to boost the metabolic flux towards bioactive diterpenes
(Universita degli studi di Salerno, 2016-02-02)This project was aimed at enhancing the synthesis of tri-cyclic bioactive abietane diterpenes (e.g. aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol), synthesized in the roots of Salvia sclarea and other Salvia ... -
“Transcutaneous laryngeal ultrasonography: a reliable, non-invasive and inexpensive preoperative method in the evaluation of vocal cords motility. A prospective multicentric analysis on a large series and an analysis of Literature”
(Universita degli studi di Salerno, 2019-07-24)INTRODUCTION Benign and malignant thyroid diseases affect a large population worldwide. Total Thyroidectomy is one of the most commonly performed intervention in general surgery. The most feared and dangerous complication ... -
Translational pharmacogenomics: a study of warfarin dosing
(Universita degli studi di Salerno, 2016-04-21)Warfarin is one of the most commonly used oral anticoagulants worldwide and is highly efficacious for the treatment and prevention of thromboembolic disorders. However, due to its narrow therapeutic index, large inter-individual ... -
Trattamento delle fratture blow-out dell’orbita: endoscopia versus chirurgia tradizionale
(Universita degli studi di Salerno, 2016-05-04)In the last decades, diagnostical imaging, surgical techniques, alloplastic materials, and surgical instruments development, allowed a great progress in management of orbital fractures. The aim of the present study was ... -
Unraveling biomarkers in Parkinson’s disease: the role of Insulin-like growth factor-1 (IGF-1) and DAT imaging
(Universita degli studi di Salerno, 2018-02-28)Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, affecting up to 10 million individuals worldwide. Although symptomatic treatment ameliorates motor symptoms, currently ... -
Untargeted metabolomics as a diagnostic tool in NAFLD: discrimination of steatosis, steatohepatitis and cirrhosis
(Universita degli studi di Salerno, 2021-05-07)Introduction: Non-Alcoholic Fatty Liver Disease encompasses a spectrum of diseases ranging from simple steatosis to steatohepatitis (or NASH), up to cirrhosis and hepatocellular carcinoma(HCC). The challenge is to recognize ... -
Valorization of typical agricultural productions and related biomasses as sources of bioactive compounds
(Universita degli studi di Salerno, 2019-11-05)Main target of this PhD project was to define the metabolome of the main by-products, and in certain cases of the edible parts, of selected agroalimentary productions, that are the flowers of Opuntia ficus indica Mill. ... -
Valutazione dell’induzione di risposta adattativa a mutageni in colture cellulari di mammifero in seguito ad esposizioni a campi elettromagnetici non ionizzanti
(Universita degli studi di Salerno, 2013-02-06)Nell’ambito del progetto di ricerca dal titolo “Valutazione dell’induzione di risposta adattativa a mutageni in colture cellulari di mammifero in seguito ad esposizioni a campi elettromagnetici non ionizzanti” è stato ...