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Design, synthesis and biological evaluation of new small-molecule modulators of Protein Methyltransferases (PMTs)
(Universita degli studi di Salerno, 2016-04-21)
A large amount of evidences indicate that dysregulation of protein methylation is linked to the genesis and progression of several human diseases, including cancer. Therefore over the past years small-molecule modulators ...
Structural studies, design, identification and biological evaluation of bioactive compounds settore
(Universita degli studi di Salerno, 2016-04-04)
Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ...
Nuove prospettive terapeutiche del glioma: N6-isopenteniladenosina ed SR141716
(Universita degli studi di Salerno, 2016-03-04)
Glioma is a fatal disease characterized by uncontrolled cellular proliferation and it is
the most common primary brain malignancy in adults. Despite years of research,
malignant glioma remains one of the most aggressive ...
Synthesis of novel ligands for the stabilization of organometallic complexes having potential antitumor activity
(Universita degli studi di Salerno, 2016-05-04)
The design of new metal complexes as anticancer agents has received considerable interest in
recent years. Complexes of titanium (e.g.: titanocene dichloride), lanthanides complexes (e.g.:
texaphyrrins lanthanide) and ...