Cerca
Items 31-40 di 138
Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)
(Universita degli studi di Salerno, 2017-03-27)
JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires ...
Studio del meccanismo d’azione e dei parametri strutturali di nuovi materiali ad azione antimicrobica
(Universita degli studi di Salerno, 2017-03-28)
The increased demand of new and more effective materials able to reduce and prevent microbiological contamination is one of the great challenges of scientific research. In the last decade, the use of antimicrobial polymers ...
In vitro and in vivo study of cannabinoids as modulators of Wnt/β-catenin pathway in human colorectal cancer
(Universita degli studi di Salerno, 2017-03-23)
Colorectal cancer (CRC) is the second most common cause of cancer death. Molecular events in CRC has been extensively studied and several data suggest that Wnt/β-catenin signaling deregulation play a pivotal role in ...
Trattamento delle fratture blow-out dell’orbita: endoscopia versus chirurgia tradizionale
(Universita degli studi di Salerno, 2016-05-04)
In the last decades, diagnostical imaging, surgical techniques, alloplastic materials,
and surgical instruments development, allowed a great progress in management of
orbital fractures. The aim of the present study was ...
Role of Annexin A1 in tumor progression
(Universita degli studi di Salerno, 2016-10-06)
Annexin 1 (ANXA1) is a multifunctional protein of 37 kDa, and represents the first characterized member of the annexin superfamily, so called since their main property is to bind (i.e. to annex) cell membranes in Ca2+-dependent ...
L'influenza del rame sull'espressione e l'attività del fattore gastrointestinaleTFF1
(Universita degli studi di Salerno, 2015-04-23)
Il tratto gastrointestinale rappresenta una interfaccia tra il corpo e l’ambiente esterno. È dotato di sofisticati meccanismi che ne regolano la funzionalità e attua efficaci strategie per la sua protezione affidandosi a ...
Studio della biodiversità mediante marcatori molecolari di popolazioni naturali e di ecotipi orticoli della regione Campania
(Universita degli studi di Salerno, 2015-04-20)
Il progetto di ricerca oggetto della mia tesi di dottorato intitolata "Studio della Biodiversità Mediante Marcatori molecolari di popolazioni naturali e di ecotipi Orticoli della Regione Campania" è stato focalizzato sulla ...
Molecular basis of cardiomiopathy
(Universita degli studi di Salerno, 2018-04-05)
The normal heart rhythm is guaranteed by an important
intercellular junctions system, named Gap Junction (GJs). Each
GJs consists of two units called connexons formed by six
specific trans-membrane proteins named connexins ...
Design and synthesis of new integrase inhibitors
(Universita degli studi di Salerno, 2017-03-28)
The viral enzyme integrase (IN) is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents an important target for the development of new antiretroviral drugs. In this PhD project, we ...
Computational design of new antimicrobial peptides
(Universita degli studi di Salerno, 2018-04-13)
Antimicrobial peptides (AMP) are evolutionarily conserved components of the
innate immune system. They have a broad spectrum of action against bacteria,
fungi and viruses. Therefore, AMP are studied as probable substitutes ...