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Novel Insights into the Biological Effects of the Isoprenoid Derivative N6-Isopentenyladenosine: Involvement of the Metabolic Sensor Ampk in Angiogenesis Inhibition
(Universita degli studi di Salerno, 2014-03-19)
N6-isopentenyladenosine (iPA) is a modified adenosine characterized by an isopentenyl chain derived by dimethylallyl pyrophosphate (DMAPP), an intermediate of the metabolic pathway of mevalonate, that is known to be ...
Design and development of new polymeric materials with potential antimicrobial and/or antifungal activity
(Universita degli studi di Salerno, 2014-12-15)
This PhD project is focused on the development of new polymeric materials with antibacterial and antifungal activity.
The first part of the work was dedicated to the synthesis and the insertion of a modified amino acid ...
Effetti a lungo termine dell’applicazione di ammendante compostato sulla qualità chimica e biologica di suoli agrari
(Universita degli studi di Salerno, 2014-10-02)
Il compost è un fertilizzante ottenuto dalla decomposizione biologica di rifiuti organici in condizioni controllate. Il processo di decomposizione biologica porta ad una parziale mineralizzazione dei composti organici più ...
The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity
(Universita degli studi di Salerno, 2014-05-21)
The thesis entitled “The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity" is divided into three chapters.
The title of the thesis clearly reflects the ...
The transcription factor Prep1 regulates adipose tissue functions
(Universita degli studi di Salerno, 2014-03-21)
Adipose tissue is crucial for maintaining energy and metabolic
homeostasis and its functionality is closely related to the adipocytes
differentiation state. Adipogenesis is regulated by several transcription factors.
Prep1 ...
p53 regulates Mevalonate Metabolic pathway
(Universita degli studi di Salerno, 2014-03-14)
The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced ...
Design and synthesis of peptides that modulate apoptotic process.
(Universita degli studi di Salerno, 2014-11-17)
Oncogenic activation of tyrosine kinases is a common feature in cancer, and its regulation represents an excellent antitumoral target. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). ...
In vitro and in cell functional proteomics on natural compounds
(Universita degli studi di Salerno, 2014-04-24)
Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification ...