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Neurodegeneration in Chronic Kidney Disease: role of neuroinflammation and uremic toxins
(Universita degli studi di Salerno, 2017-03-28)
Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ...
Rischio clinico, gestione del rischio e sue implicazioni. Un aspetto della medicina traslazionale
(Universita degli studi di Salerno, 2017-06-05)
This thesis is based on the awareness that prevention in the ethical and vocational training of health workers is extremely important, above all the one concerned with the clinical risk as well as a competent and intelligent ...
Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents
(Universita degli studi di Salerno, 2017-03-22)
One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the ...
In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(Universita degli studi di Salerno, 2017-03-31)
Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert
beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties
of bioactive ...
Chronotherapeutic Drug Delivery in Early Morning Pathologies: Design and Production of new NSAIDs/SAIDs polysaccharide-based systems
(Universita degli studi di Salerno, 2017-03-28)
The major technological challenge encountered when formulating new dosage forms is to find a way to adapt drug release kinetics to specific clinical requirements, with the aim to enhance the therapeutic action of both new ...
Role of TFF1 in tumor progression
(Universita degli studi di Salerno, 2017-03-31)
Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ...
Design and synthesis of peptides involved in the inhibition of influenza virus infection
(Universita degli studi di Salerno, 2017-03-28)
The main purpose of the present research project was the identification of peptide capable of exercising potent anti-influenza activity. We identified bovine lactoferrin (bLf) as drug target, a multifunctional glycoprotein ...
Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis
(Universita degli studi di Salerno, 2017-03-28)
Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as ...
Bioactives from agricultural food by-products: application in food and health
(Universita degli studi di Salerno, 2017-04-04)
Agriculture and agri-food industry produce a large amount of residues in non-edible portions from cultivation and processing of crops. These wastes, considered by-products, give serious environment damage, if not properly ...
Creazione di modelli virtuali 3D da immagini TC e RM per la pianificazione degli interventi chirurgici in Chirurgia Pediatrica
(Universita degli studi di Salerno, 2017-05-23)
BACKGROUND. Lo sviluppo di sistemi medicali sempre più avanzati per l’acquisizione delle immagini finalizzati all’estrazione di informazioni tridimensionali sugli organi del corpo umano tramite metodi non invasivi, hanno ...