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dc.contributor.authorMagliacane, Diomira
dc.contributor.authorParente, Roberto
dc.contributor.authorTriggiani, Massimo
dc.date.accessioned2014-06-04T10:43:22Z
dc.date.available2014-06-04T10:43:22Z
dc.date.issued2014
dc.identifier.citationMagliacane D, Parente R, and Triggiani M. Current Concepts on Diagnosis and Treatment of Mastocytosis. Translational Medicine @ UniSa 2014;8(8):65-74en_US
dc.identifier.issn2239-9747en_US
dc.identifier.urihttp://hdl.handle.net/10556/1384
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-233
dc.description.abstractMastocytosis is a heterogeneous group of disorders characterized by a clonal proliferation and accumulation of mast cells in one or more organ, primarily in the skin and bone marrow. The clinical spectrum of the disease varies from relatively benign forms with isolated skin lesions to very aggressive variants with extensive systemic involvement and poor prognosis. The growth and proliferation of clonal mast cells is caused by an activating mutation of the tyrosine kinase receptor Kit for Stem Cell Factor, the main growth factor for mast cells. Clinical symptoms are related to mast-cell mediator release, to the tissue mast cell infiltration or both. The degree of infiltration and cell activation determines the highly variable clinical and morphological features. Current treatment of mastocytosis includes symptomatic, antimediator drugs and cytoreductive targeted therapies.en_US
dc.format.extentP. 65-74en_US
dc.language.isoenen_US
dc.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dc.subjectMastocytosisen_US
dc.titleCurrent Concepts on Diagnosis and Treatment of Mastocytosisen_US
dc.typeArticleen_US
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