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dc.contributor.authorValarezo Valdez, Benito Eduardo
dc.date.accessioned2014-07-09T10:51:21Z
dc.date.available2014-07-09T10:51:21Z
dc.date.issued2013-03-19
dc.identifier.urihttp://hdl.handle.net/10556/1474
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-317
dc.description2011 - 2012en_US
dc.description.abstractThe technical parameters for electrospinning solutions of biodegradable polymers poly(ε-caprolactone), poly(lactic acid) and their composites with active molecules were defined and set up. A trial-and-error approach has been employed by varying solution properties and processing parameters to obtain uniform defect-free fibers. Amoxicillin drug was intercalated in layered double hydroxide nanoparticles by coprecipitation and then the modified nanohybrid was successfully encapsulated at different concentrations into poly(ε-caprolactone) matrix by the electrospinning technique. Non-woven fibrous mats were fabricated and characterized in terms of morphology, in vitro release and antibacterial properties. Blends of poly(lactic acid) and poly(ε-caprolactone), loaded with different amounts of amoxicillin were electrospun to investigate the release behaviour and obtain a controlled and tuneable release. Morphology and thermal behaviour were found dependent on the component ratio as well as on the incorporated drug amount. [edited by author]en_US
dc.language.isoenen_US
dc.publisherUniversita degli studi di Salernoen_US
dc.subjectElectrospinningen_US
dc.subjectComposite nanofibersen_US
dc.subjectPolymer concentrationen_US
dc.subjectDrug deliveryen_US
dc.subjectFibersen_US
dc.titleInnovative processes for the production of new nanocomposite materials by electrospinning techniqueen_US
dc.typeDoctoral Thesisen_US
dc.subject.miurCHIM/07 FONDAMENTI CHIMICI DELLE TECNOLOGIEen_US
dc.contributor.coordinatoreCiambelli, Paoloen_US
dc.description.cicloXI n.s.en_US
dc.contributor.tutorVittoria, Vittoriaen_US
dc.identifier.DipartimentoIngegneria Chimica ed Alimentareen_US
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