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Designing in-vitro systems to simulate the in-vivo permeability of drugs
| dcterms.contributor.author | Cascone, Sara | |
| dcterms.contributor.author | Lamberti, Gaetano | |
| dcterms.contributor.author | Titomanlio, Giuseppe | |
| dc.date.accessioned | 2015-01-29T11:34:13Z | |
| dc.date.available | 2015-01-29T11:34:13Z | |
| dcterms.date.issued | 2014 | |
| dcterms.identifier.citation | Cascone S, Lamberti G, Titomanlio G. Designing in-vitro systems to simulate the in-vivo permeability of drugs. Translational Medicine @ UniSa 2014;10(5):14-21 | |
| dcterms.identifier.issn | 2239-9747 | en_US |
| dcterms.identifier.uri | http://hdl.handle.net/10556/1636 | |
| dcterms.identifier.uri | http://dx.doi.org/10.14273/unisa-440 | |
| dc.description.abstract | In this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several active molecules have been evaluated across a synthetic membrane. The permeability of these drugs measured through the artificial membrane were successfully correlated to their in-vivo permeability. The relationship with in-vivo permeability was derived, and then a rule to design systems to simulate the intestinal absorption was proposed to reduce the need for expensive and ethical problematic in-vivo measurements | en_US |
| dcterms.format.extent | P. 14-21 | en_US |
| dc.language.iso | en | en_US |
| dcterms.source | UniSa. Sistema Bibliotecario di Ateneo | en_US |
| dcterms.subject | Permeability | en_US |
| dcterms.subject | Artificial membranes | en_US |
| dcterms.subject | Franz cell | en_US |
| dcterms.subject | In-vitro/in-vivo correlations | en_US |
| dcterms.subject | Stokes radius | en_US |
| dcterms.subject | Oral delivery | en_US |
| dcterms.title | Designing in-vitro systems to simulate the in-vivo permeability of drugs | en_US |
| dcterms.type | Article | en_US |