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dc.contributor.authorD'Acunto, Mariantonietta
dc.date.accessioned2015-05-06T08:25:02Z
dc.date.available2015-05-06T08:25:02Z
dc.date.issued2012-02-02
dc.identifier.urihttp://hdl.handle.net/10556/1764
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-559
dc.description2010 - 2011en_US
dc.description.abstractThe aim of this PhD project has been to develop new synthetic strategies in enantioselective preparation of natural products. In particular my attention has been focused on preparation of some natural metabolite, containing an α,β-unsaturated dialdehyde in a polycyclic backbone, and their synthetic analogue, in order to better understand structure activity relationship towards TRP receptors ion channels. The recent discover of the new thermoreceptor TRPA1 and given that these natural metabolites show also a widespread of bioactivities, such as antiproliferative and cytotoxic activity, has increased our interest towards these target ever more. Our purpose is to assay the bioactivity of synthesized products both as TRP receptor agonists and as antiproliferative compounds . The first chapter of this work is an introduction to these terpenoidic molecules, with a wide range of described natural occurring metabolite and their classification in drimane, isocopalane, and scalarane dialdehydes. Thus, the structure of TRP receptor is described with a brief history of these ion channels, starting from the first cloned receptor , the TRPV1 vanilloid. In the chapter 2 total syntheses of polygodial derivatives, both C-1 and C-3 functionalised, are described. Polygodial and C-1 functionalised drimanes have been prepared with an approach whose key step is a Diels Alder reaction; Drimane C-3 functionalised have been prepared with a radical chemistry approach... [edited by author]en_US
dc.language.isoenen_US
dc.publisherUniversita degli studi di Salernoen_US
dc.subjectTerpenoidic dialdehidesen_US
dc.subjectTRP receptorsen_US
dc.subjectButyrolactonesen_US
dc.titleTotal synthesis of terpenoidic unsatured dialdehydes and evaluation of their activity towards TRP receptorsen_US
dc.typeDoctoral Thesisen_US
dc.subject.miurCHIM/06 CHIMICA ORGANICAen_US
dc.contributor.coordinatoreGuerra, Gaetanoen_US
dc.description.cicloX n.s.en_US
dc.contributor.tutorSpinella, Aldoen_US
dc.identifier.DipartimentoChimica e Biologiaen_US
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