Show simple item record

dc.contributor.authorCaporale, Angelamaria
dc.date.accessioned2016-09-15T08:50:09Z
dc.date.available2016-09-15T08:50:09Z
dc.date.issued2016-05-04
dc.identifier.urihttp://hdl.handle.net/10556/2191
dc.description2014 - 2015it_IT
dc.description.abstractThe design of new metal complexes as anticancer agents has received considerable interest in recent years. Complexes of titanium (e.g.: titanocene dichloride), lanthanides complexes (e.g.: texaphyrrins lanthanide) and carbenic complexes of gold, silver and copper showed significant biological activity, and have progressed into clinical trials. Thus, the target of this PhD project are the synthesis of new ligands and metal complexes. Firstly 5 cyclopentadienyl pro-ligands were synthesised: 6-phenylfulvene, 6-(p-metoxyphenyl)-fulvene e 6- (3',4'-dymethoxyphenyl)fulvene, 6-(3',5')-dymethoxyphenyl)fulvene and 6-(2',4')- dymethoxyphenyl)fulvene. Then, the synthesis of 12 novel scandium, yttrium and neodymium complexes with these cyclopentadienyl ligands was carried out. The complexes were tested on DU146 (Prostatic carcinoma) and MDA.MB213 (Breast cancer) to verify inhibition of cell-proliferation, using MTT test with standard procedures. All the complex showed a strong concentration-dependent ability of inhibiting the growth tumor cell, referring to antiblastic activity. [edited by author]it_IT
dc.language.isoenit_IT
dc.publisherUniversita degli studi di Salernoit_IT
dc.subjectGroup III metal complexesit_IT
dc.subjectGold complexesit_IT
dc.titleSynthesis of novel ligands for the stabilization of organometallic complexes having potential antitumor activityit_IT
dc.typeDoctoral Thesisit_IT
dc.subject.miurCHIM/08 CHIMICA FARMACEUTICAit_IT
dc.contributor.coordinatoreSbardella, Gianlucait_IT
dc.description.cicloXIV n.s.it_IT
dc.contributor.tutorSaturnino, Carmelait_IT
dc.identifier.DipartimentoFarmaciait_IT
 Find Full text

Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record