Browsing Scienze del farmaco by Title
Now showing items 1-20 of 33
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Alginate hydrogels in drug delivery: from physico- chemical to technological studies of a promising polysaccharide for 3D printing applications.
(Universita degli studi di Salerno, 2022-10-20)Focusing the attention on the futuristic concept of personalized medicine, the Ph.D. project aimed to demonstrate the potentialities of hydrogels as a versatile feed material for the semi solid extrusion 3D printing ... -
Analytical procedures for the safety assessment of dietary supplements and botanicals
(Universita degli studi di Salerno, 2023-04-06)The consumption of dietary supplements and botanicals is not always safe and free of potential health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a group of plant secondary ... -
Analytical procedures for the safety assessment of dietary supplements and botanicals
(Universita degli studi di Salerno, 2023-04-06)The consumption of dietary supplements and botanicals is not always safe and free of potential health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a group of plant secondary ... -
Application of Artificial Neural Networks to the design and optimization of superhydrophobic coatings
(2021-05-19)Recently, considerable attention has been devoted to developing superhydrophobic surfaces due to their advantageous antimicrobial and self-cleaning properties. While significant effort has been devoted to their fabrication, ... -
Bioactives from agricultural food by-products: application in food and health
(Universita degli studi di Salerno, 2017-04-04)Agriculture and agri-food industry produce a large amount of residues in non-edible portions from cultivation and processing of crops. These wastes, considered by-products, give serious environment damage, if not properly ... -
Bioprospecting of plants from Campania region to promote the sustainable use of biodiversity
(Universita degli studi di Salerno, 2023-04-12)This research aimed to chemical-biological study of plant and fungal species from inland areas of Campania Region, typically used in preparations for medicinal purposes or food traditional recipes. In the preliminary ... -
Chronotherapeutic Drug Delivery in Early Morning Pathologies: Design and Production of new NSAIDs/SAIDs polysaccharide-based systems
(Universita degli studi di Salerno, 2017-03-28)The major technological challenge encountered when formulating new dosage forms is to find a way to adapt drug release kinetics to specific clinical requirements, with the aim to enhance the therapeutic action of both new ... -
Computational design of new antimicrobial peptides
(Universita degli studi di Salerno, 2018-04-13)Antimicrobial peptides (AMP) are evolutionarily conserved components of the innate immune system. They have a broad spectrum of action against bacteria, fungi and viruses. Therefore, AMP are studied as probable substitutes ... -
Design and production of personalised medicines via innovative 3D printing technologies
(Universita degli studi di Salerno, 2021-05-04)The perspective of personalized therapies in recent years is projecting the community towards a rampant hankering for individualization of healthcare. Paramount is the necessity of re-organizing the healthcare services ... -
Design and synthesis of small molecules as ion channel modulators
(Universita degli studi di Salerno, 2022-05-02)My PhD research plan relates the exploration of the structural requirements for ionic channels modulation such as TRPM8 and Kv7 receptors. About the first field, we prepared a series of tryptophan-based derivatives of ... -
Design, synthesis and biological activity of new target selective antitumoral agents
(Universita degli studi di Salerno, 2018-04-05)Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ... -
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(Universita degli studi di Salerno, 2018-04-20)Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ... -
Design, synthesis and pharmacological evaluation of new enzyme inhibitors
(Universita degli studi di Salerno, 2023-04-13)My PhD research plan relates to the exploration of the structural requirements for the modulation of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part of my doctoral ... -
Design, Synthesis, and characterization of peptides from Gp36 FIV glycoprotein
(Universita degli studi di Salerno, 2022-04-26)Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile che include il peptide di ... -
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(Universita degli studi di Salerno, 2022-05-03)La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La metilazione dell'arginina ... -
Development of analytical strategies for phytochemical investigation of «superfoods», with particular attention to Botanicals.
(Universita degli studi di Salerno, 2022-04-27)There is a great attention to functional foods exerting health benefits. In this frame the claim ‘superfood’ to characterize products with high nutritional value and bioactive phytochemicals is more and more used. In ... -
Development of Innovative Agents for the Treatment of Metabolic Diseases
(Universita degli studi di Salerno, 2022-05-10)Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the leading cause of death in the world. To date three main therapeutic strategies have been evaluated to reduce circulating LDL-C ... -
Development of novel anticancer compounds directed towards promising therapeutic targets
(Universita degli studi di Salerno, 2023-04-19)Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant activity in proteins involved in this ... -
Drug delivery to the lung in Cystic Fibrosis: deposition, dissolution, mucus interaction and microbiological evaluation of dry powder inhalers
(Universita degli studi di Salerno, 2018-04-05)The inhalation therapy consists of a direct administration of drugs for the treatment of lung diseases. A formulation for inhalation is a valid option in the symptomatic management of pulmonary diseases typical of cystic ... -
High-throughput virtual screening by molecular dynamics assisted molecular docking.
(Universita degli studi di Salerno, 2022-04-29)Molecular docking is a widely used Structure-Based method for drug discovery. Over the years, molecular docking methodologies have evolved to address several limitations, such as high errors in predicting pose and binding ...
