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dc.contributor.authorManniello, Michele Dario
dc.date.accessioned2018-12-05T13:59:23Z
dc.date.available2018-12-05T13:59:23Z
dc.date.issued2018-04-05
dc.identifier.urihttp://hdl.handle.net/10556/3007
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-1298
dc.description2016 - 2017it_IT
dc.description.abstractThe inhalation therapy consists of a direct administration of drugs for the treatment of lung diseases. A formulation for inhalation is a valid option in the symptomatic management of pulmonary diseases typical of cystic fibrosis (CF). This is a rare hereditary disease that affects the normal function of the exocrine glands of the mucosa, with the production of a dry and poorly flowing mucus even in the respiratory tract. The first objective of my PhD project was to evaluate the rheological behaviour of the CF sputum samples, kindly donated by the “G. Gaslini” Hospital of Genoa. Following the in vitro addition of HCO3 - to the sputum samples, a decrease in the viscosity of this material was therefore evaluated, compared to samples pre-treated with water alone. To verify if this evidence was accompanied by an increase in permeation of a drug through this sample, the second purpose was to evaluate the permeation of a drug through CF sputum. The Ketoprofen lysinate, a formulation in dry powder, called Dry Powder Inhaler (DPI), already developed in previous research work was selected. As the results show, the viscosity decrease was therefore accompanied by an increase in the permeation of the drug only after the addition of HCO3 - to the sputum samples... [edited by Author]it_IT
dc.language.isoenit_IT
dc.publisherUniversita degli studi di Salernoit_IT
dc.subjectDry powder inhalersit_IT
dc.subjectDry Powderit_IT
dc.subjectAntibioticit_IT
dc.subjectCystic fibrosisit_IT
dc.titleDrug delivery to the lung in Cystic Fibrosis: deposition, dissolution, mucus interaction and microbiological evaluation of dry powder inhalersit_IT
dc.typeDoctoral Thesisit_IT
dc.subject.miurCHIM/09 FARMACEUTICO TECNOLOGICO APPLICATIVOit_IT
dc.contributor.coordinatoreSbardella, Gianlucait_IT
dc.description.cicloXXX cicloit_IT
dc.contributor.tutorRusso, Paolait_IT
dc.identifier.DipartimentoFarmaciait_IT
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