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dc.contributor.authorGambardella, Jessica
dc.contributor.authorFranco, Antonietta
dc.contributor.authorDel Giudice, Carmine
dc.contributor.authorFiordelisi, Antonella
dc.contributor.authorCipolletta, Ersilia
dc.contributor.authorCiccarelli, Michele
dc.contributor.authorTrimarco, Bruno
dc.contributor.authorIaccarino, Guido
dc.contributor.authorSorriento, Daniela
dc.date.accessioned2019-11-07T15:07:52Z
dc.date.available2019-11-07T15:07:52Z
dc.date.issued2016
dc.identifier.citationGambardella J, Franco A, Del Giudice C, Fiordelisi A, Cipolletta E, Ciccarelli M, Trimarco B, Iaccarino G, Sorriento D. Dual role of grk5 in cancer development and progression. Translational Medicine @ UniSa 2016, 14(6): 28-37it_IT
dc.identifier.issn2239-9747it_IT
dc.identifier.urihttp://elea.unisa.it:8080/xmlui/handle/10556/3788
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-2010
dc.description.abstractGRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the nucleus. Thus, GRK5 is involved in the development and progression of several pathological conditions including cancer. Several reports underline the involvement of GRK5 in the regulation of tumor growth even if they appear controversial. Indeed, depending on its subcellular localization and on the type of cancer, GRK5 is able to both inhibit cancer progression, through the desensitization of GPCR and non GPCR-receptors (TSH, PGE2R, PDGFR), and induce tumor growth, acting on non-receptor substrates (p53, AUKA and NPM1). All these findings suggest that targeting GRK5 could be an useful anti-cancer strategy, for specific tumor types. In this review, we will discuss the different effects of this kinase in the induction and progression of tumorigenesis, the molecular mechanisms by which GRK5 exerts its effects, and the potential therapeutic strategies to modulate them.it_IT
dc.format.extentP. 28-37it_IT
dc.language.isoenit_IT
dc.sourceUniSa. Sistema Bibliotecario di Ateneoit_IT
dc.subjectGRK5it_IT
dc.subjectGPCRit_IT
dc.subjectCancerit_IT
dc.titleDual role of grk5 in cancer development and progressionit_IT
dc.typeJournal Articleit_IT
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