Browsing Translational Medicine @ UniSa by Title
Now showing items 1-20 of 284
-
1,4-Dihydropyridines: the multiple personalities of a blockbuster drug family
(2012)More than 40 years after their introduction in therapy, 1,4-dihydropyridines (DHPs) are still amongst the most prescribed drugs in the world. Though they all share a similar mechanism of action blocking L-type voltage-gated ... -
18F-FDG PET and PET/CT in the localization and characterization of lesions in patients with ovarian cancer
(2012)Aim: The aim was to compare the imaging findings of 18F-fluorodeoxyglucose (18F-FDG) PET and integrated PET/CT in patients with primary, recurrent or metastatic ovarian cancer. Materials and methods. 21 women with ovarian ... -
67 kDa laminin receptor (67LR) in normal and neoplastic hematopoietic cells: is its targeting a feasible approach?
(2016)The 67 kDa laminin receptor (67LR) is a non-integrin cell surface receptor for laminin (LM) that derives from a 37 kDa precursor (37LRP). 67LR expression is increased in neoplastic cells and correlates with an enhanced ... -
A Case Series of Blastic Plasmacytoid Dendritic Cell Neoplasia
(2020)Blastic plasmacytoid dendritic cell neoplasm (BPDCN), an extremely rare and aggressive tumor, derives from plasmacytoid dendritic cell precursors and is characterized by CD4 and CD56 positivity accompanied by the expression ... -
A nutritional approach to the prevention of cancer: from assessment to personalized intervention
(2015)Among lifestyle factors, nutrition is one of the most important determinants of health, and represents a pivotal element of cancer risk. Nonetheless, epidemiological evidences of the relationship between several cancers ... -
A single-center experience on below-the-knee endovascular treatment in diabetic patients
(2020)Diabetic ulceration of the foot is a major global medical, social and economic problem and is the most frequent end-point of diabetic complications. A retrospective analysis from February 2017 to May 2019 of diabetic ... -
A study protocol for development and validation of a clinical prediction model for frailty (ModulEn): a new European commitment to tackling frailty
(2019)There is a growing need to implement and evaluate the technological solutions that allow the early detection of age-related frailty and enable assessment of the predictive values of frailty components. The broad use ... -
Accelerated bone mass senescence after hematopoietic stem cell transplantation
(2013)Osteoporosis and avascular necrosis (AVN) are long-lasting and debilitating complications of hematopoietic stem cell transplantation (HSCT). We describe the magnitude of bone loss, AVN and impairment in osteogenic ... -
Acute deep vein thrombosis and pulmonary embolism: is the thromboaspiration device an appropriate choice?
(2020)Nowadays patients affected by deep vein thrombosis (DVT) and pulmonary embolism (PE) are studied widely but the challenge for physicians is when and how they are to be treated. Most patients present serious comorbidities ... -
Adrenergic mechanism in the control of endothelial function
(2011)There is considerable evidence that many disease are associated with endothelial dysfunction and reduced nitric oxide production such as hypertension, obesity, dyslipidemias, diabetes, heart failure, atherosclerosis. Notably ... -
Advanced applications of robotics in digestive surgery
(2011)Laparoscopy is widely recognized as feasible and safe approach to many oncologic and benign digestive conditions and is associated with an improved early outcome. Robotic surgery promises to overcome intrinsic limitations ... -
Allergens in allergy diagnosis: a glimpse at emerging new concepts and methodologies
(2012)Allergic diseases are important concern of public health. A reliable diagnosis is of utmost importance for the management of allergic patients both when immunotherapy is planned and when the treatment is essentially based ... -
An approach to prevent frailty in community dwelling older adults: a pilot study performed in Campania region in the framework of the PERSSILAA project
(2019)We developed and tested an innovative physical training method in older adults that embeds the gym program into everyday life in the most conservative way possible. Physical training was included in the activities of ... -
An interregional, transdisciplinary and good practice-based approach for frailty: the mind&gait project
(2019)Social facilities such residential structures and day-centres increasingly seek integrated, structured, adapted, creative, dynamic and economic strategies to prevent frailty. The arising need of an aged and frail ... -
Anatomy and surgery of the endoscopic endonasal approach to the skull base
(2012)The midline skull base is an anatomical area, which extends from the anterior limit of the anterior cranial fossa down to the anterior border of the foramen magnum. For many lesions of this area, a variety of skull base ... -
Anesthesiological considerations in shoulder surgery
(2012)In 1970, Winnie proposed the brachial plexus block as an alternative and effective anaesthesia technique for shoulder surgery. From that date, several techniques have been developed to approach the brachial plexus: the use ... -
Aneurysmal subarachnoid haemorrhage in pregnancy: a case series
(2012)Pregnancy is a recognized risk factor for aneurysmal subarachnoid hemorrhage (SAH). Headache is very frequent in normal pregnancy and it is a common sign shared between several intracranial diseases. We present a case ... -
Angiogenesis in Chronic Obstructive Pulmonary Disease: A Translational Appraisal
(2012)Angiogenesis is a crucial component of lung pathophysiology, not only in cancer but also in other disorders, such as chronic obstructive pulmonary disease (COPD). In COPD angiogenesis is definitely able to control and ...
