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Accelerated bone mass senescence after hematopoietic stem cell transplantation
(2013)
Osteoporosis and avascular necrosis
(AVN) are long-lasting and debilitating complications of hematopoietic stem cell transplantation
(HSCT).
We describe the magnitude of bone loss, AVN
and impairment in osteogenic ...
Use of equine pericardium sheet (lyomesh®) as dura mater substitute in endoscopic endonasal transsphenoidal surgery
(2013)
Objective: The aim of this study was to describe the use of equine pericardium sheet (Lyomesh®) as dural substitute for sellar reconstruction after endoscopic endonasal transsphenoidal surgery for the removal of pituitary ...
Pharmacokinetics of remifentanil: a three-compartmental modeling approach
(2013)
Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics ...
The determinants of translational medicine success - A managerial contribution
(2013)
Scope of Translational Medicine is to speed the development of new compounds of medical protocols and/or treatments to improve patient’s quality of life. Translational medicine represents the synergy between epidemiology, ...
Molecular Genetics of Myelofibrosis and its associated Disease Phenotypes
(2014)
In 2005, the discovery of Janus kinase 2 (JAK2) V617F mutation in approximately half of patients with myelofibrosis (MF) marked an important milestone in our understanding of the pathophysiology of MF. This has broadened ...
Molecular Pathogenesis of Myelodysplastic Syndromes
(2014)
Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders characterized by inefficient hematopoiesis, hypercellular bone marrow, dysplasia of blood cells and cytopenias. Most patients are diagnosed in ...
Current Concepts on Diagnosis and Treatment of Mastocytosis
(2014)
Mastocytosis is a heterogeneous group of disorders characterized by a clonal proliferation and accumulation of mast cells in one or more organ, primarily in the skin and bone marrow. The clinical spectrum of the disease ...
Immunological derangement in Hypocellular Myelodysplastic Syndromes
(2014)
Hypocellular or hypoplastic myelodysplastic syndromes (HMDS) are a distinct subgroup accounting for 10–15% of all MDS patients, that are characterized by the presence of bone marrow (BM) hypocellularity, various degree of ...