Translational Medicine @ UniSa: Recent submissions
Now showing items 141-160 of 295
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Microvascular blood flow improvement in hyperglycemic obese adult patients by hypocaloric diet
(2016)The present study was aimed to assess the changes in skin microvascular blood flow (SBF) in newly diagnosed hyperglycemic obese subjects, administered with hypocaloric diet. Adult patients were recruited and divided in ... -
67 kDa laminin receptor (67LR) in normal and neoplastic hematopoietic cells: is its targeting a feasible approach?
(2016)The 67 kDa laminin receptor (67LR) is a non-integrin cell surface receptor for laminin (LM) that derives from a 37 kDa precursor (37LRP). 67LR expression is increased in neoplastic cells and correlates with an enhanced ... -
Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer
(2016)The urokinase (uPA)-type plasminogen activator receptor (uPAR) is a GPIanchored receptor that focuses urokinase (uPA) proteolytic activity on the cell surface. uPAR also regulates cell adhesion, migration and proliferati ... -
In vitro apoptotic effects of farnesyltransferase blockade in acute myeloid leukemia cells
(2016)Farnesyltransferase inhibitors (FTIs) are a class of oral anti-cancer drugs currently tested in phase I-II clinical trials for treatment of hematological malignancies. The in vitro effects of various FTIs (alpha-hydroxyf ... -
The urokinase/urokinase receptor system in mast cells: effects of its functional interaction with fmlf receptors
(2016)Mast cell and basophils express the high affinity receptor for IgE (FcRI) and are primary effector cells of allergic disorders. The urokinase (uPA)-mediated plasminogen activation system is involved in physiological and ... -
Use of the directional atherectomy for the treatment of femoro-popliteal lesions in patients with critical lower limb ischemia
(2016)Femoro-popliteal PTA for the treatment of critical limb ischemia is frequently associated with unsatisfactory procedural success rates while directional atherectomy (DCA) has improved success rate since claudicant patients ... -
Stress-first single photon emission computed myocardial perfusion imaging
(2016)Background. Myocardial perfusion imaging (MPI) with single photon emission tomography (SPET) is widely used in coronary artery disease evaluation. Recently major dosimetric concerns have arisen. The aim of this study was ... -
The european innovation partnership on active and healthy ageing synergies: protocol for a prospective observational study to measure the impact of a community-based program on prevention and mitigation of frailty (ICP –PMF) in community-dwelling older adults
(2016)Aim of this paper is to describe the protocol of the study “Impact of a Community-based Program on Prevention and Mitigation of Frailty in communitydwelling older adults” developed in the framework of the European Innovation ... -
Effect of α2-adrenergic agonists and antagonists on cytokine release from human lung macrophages cultured in vitro
(2016)The most trusted hypothesis to explain how α2-adrenergic agonists may preserve pulmonary functions in critically ill patients is that they directly act on macrophages by interfering with an autocrine/paracrine adrenergic ... -
Evaluation of symptoms and prevention of cancer in menopause: the value of vulvar exam
(2016)Vulvar and vaginal atrophy (VVA), is a chronic medical condition experienced by postmenopausal women, with prevalence estimated ranging from 10% to 50% [1]. VVA is characterized by a constellation of symptoms, that may ... -
Prolonged complete hematologic response in relapsed/refractory T-large granular lymphocyte leukemia after bendamustine treatment
(2016)T-large granular lymphocyte leukemia (T-LGLL) is a chronic clonal proliferation of effector memory cytotoxic CD3+CD57+CD56- T cells and the current guidelines suggest immunosuppressive therapy as first-line therapy, but the ... -
Quality of life perception in type 2 diabetes
(2016)Purpose: Lifestyle analysis is often used for primary and secondary prevention in many chronic metabolic diseases, including diabetes. Questionnaires are simple and common methods for first investigation risk of factors ... -
Posterior mediastinal extramedullary hematopoiesis secondary to hypoxia
(2016)Two mediastinal masses were incidentally detected at high resolution computed tomography (HRCT) of a 72 year-old male patient, former smoker, affected by chronic obstructive pulmonary disease with worsening dyspnea and ... -
Clinical and radiographic mid-term outcomes after total shoulder replacement: a retrospective study protocol including 400 anatomical and reverse prosthetic implants
(2016)Objectives: To obtain outcomes data on anatomical and reverse total shoulder arthroplasty by analysis of clinical scores and standard radiographs. Subject selection and enrollment: 400 consecutive series of patients replaced ... -
Sensitizazion to common and uncommon pets or other furry animals: which may be common mechanisms?
(2016)Exposure to animal allergens constitutes a relevant risk factor for the development of allergic sensitization. Moreover, an increasing number of people become owners of less common animals. In this article we summarize ... -
Looking for calcium phosphate composite suitable to study osteoclast endocytosis: preliminary observations
(2016)One of the issues regarding in vitro study of bone resorption is the synthesis of a bonelike biomaterial forming a thin layer onto either glass or plastic. The synthesis of a bone-like material suitable for in vitro studies ... -
The tosca registry: an ongoing, observational, multicenter registry for chronic heart failure
(2015)The ageing of the population in western countries, the continuous increase of the prevalence of chronic diseases, the frequent coexistence of several morbid conditions (comorbidity) requires health professionals and ... -
Dual role of grk5 in cancer development and progression
(2016)GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the ... -
Ergonomic t-handle for minimally invasive surgical instruments
(2016)A T-handle has been designed to be used for minimally invasive implantation of a dynamic hip screw to repair fractures of the proximal femur. It is capable of being used in two actions: (i) push and hold (while using an ...
