Translational Medicine @ UniSa: Recent submissions
Now showing items 201-220 of 295
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Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization
(2014)G protein coupled receptor kinase 2 (GRK2) has a key role in cellular function by regulating different intracellular mechanisms in a kinase dependent or independent manner. In this review we have dealt with the recently ... -
Reasoning has become a luxury
(2014) -
Molecular biology of gliomas: present and future challenges
(2014)Malignant brain tumours are one of the most relevant causes of morbidity and mortality across a wide range of individuals. Malignant glioma is the most common intra axial tumor in the adult. Many researches on this theme ... -
An evaluation of coronary atherosclerosis using coronary CT in subjects with asymptomatic carotid lesions
(2014)The evaluation of coronary lesions in patients with asymptomatic carotid plaque represents a very promising line of research to assess cardiovascular risk and the possible implementation of a more aggressive prevention therapy. -
Designing in-vitro systems to simulate the in-vivo permeability of drugs
(2014)In this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several active ... -
Complementary Therapy in Polycystic Ovary Syndrome
(2014)Polycystic Ovary Syndrome (PCOS) is an endocrine disease. PCOS afflicts 5 to 10 % of women of reproductive age. The symptoms are: amenorrhea, oligomenorrhea, hirsutism, obesity, infertility, chronic hyperandrogenic anovulation ... -
Hydrocephalus onset after microsurgical or endovascular treatment for acute subarachnoid hemorrhage. Retrospective Italian Multicenter Study
(2014)Background: Chronic shunt-dependent hydrocephalus is a complication of aneurysmal subarachnoid hemorrhage (aSAH). Its incidence and risk factors have been described while the hydrocephalus onset in terms of days after ... -
Pre-Participation Musculoskeletal and Cardiac Screening of Male Athletes in the United Arab Emirates
(2014)This study presents the results of pre-participation musculoskeletal and cardiac screening using the Lausanne recommendations, which include a personal and family history, physical examination and electrocardiography. Cross ... -
Combined Administration of Oxycodone/Naloxone in Chronic Osteo-Articular Diseases Pain Therapy
(2014)The aim of this study is the analysis of the beneficial impact of using opioid receptor antagonist associated to opioid analgesic on the quality of life in patients suffering from chronic non-cancer pain. We recruited 60 ... -
Management of Atrial Fibrillation in Patients Undergoing Percutaneous Coronary Intervention
(2014)Atrial fibrillation (AF) is the most common cardiac arrhythmia, occurring in 1-2% of overall population, involving more than 6 millions of European people. It is associated to a reduced quality of life and an increased ... -
A Low Cost Amplifier And Acquisition System For Cortical-Electroncephalography In Non-Human Applications
(2014)A simple circuit is described to make an AC-amplifier and an analog-to-digital converter in a single, compact solution, for use in basic research, but not on humans. The circuit sends data to and is powered from a common ... -
Genomics DNA Profiling in Elite Professional Soccer Players: A Pilot Study
(2014)Functional variants in exonic regions have been associated with development of cardiovascular disease, diabetes and cancer. Athletic performance can be considered a multi-factorial complex phenotype. Genomic DNA was extracted ... -
Redesigning Service Delivery for Hypertensive Patients: A Methodological Guideline to Improve the Management of Chronic Diseases
(2014)Best care is not necessarily the most expensive, but the most appropriate, and prevention is the most powerful tool to promote health. A novel approach might envision the reduction of hospital admittance (thus meeting a ... -
Immunologic Changes in Frail Older Adults
(2014)Several studies have shown a heightened inflammatory state in frail older adults, marked by high serum levels of interleukin-6 and C-reactive protein and an increased number of circulating leukocytes. Activation of monocytes ... -
Discovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challenges
(2014)Monoclonal gammopathy of undetermined significance (MGUS) is a non malignant plasma cell disorder with a relatively low risk of progression to Multiple Myeloma (MM) and to related Plasma cells disordes (lymphoplasmacellular ... -
Are T-LGL leukemia and NK-chronic lymphoproliferative disorder really two distinct diseases?
(2014)Mature Large Granular lymphocytes (LGL) disorders include a spectrum of conditions, ranging from polyclonal to clonal indolent and/or overt leukemic LGL proliferations. Most cases are represented by clonal expansions of ...
