Translational Medicine @ UniSa: Recent submissions
Now showing items 221-240 of 295
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Clonal non-malignant hematological disorders: unraveling molecular pathogenic mechanisms to develop novel targeted therapeutics
(2014)Clonal non-malignant hematological disorders are a heterogeneous group of diseases that are particularly challenging for hematologists. Indeed, most obvious and frequent hematological diseases include a broad spectrum of ... -
Errata corrige
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Monoclonal B-cell lymphocytosis
(2014)Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 109/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, ... -
Current Concepts on Diagnosis and Treatment of Mastocytosis
(2014)Mastocytosis is a heterogeneous group of disorders characterized by a clonal proliferation and accumulation of mast cells in one or more organ, primarily in the skin and bone marrow. The clinical spectrum of the disease ... -
Molecular Genetics of Myelofibrosis and its associated Disease Phenotypes
(2014)In 2005, the discovery of Janus kinase 2 (JAK2) V617F mutation in approximately half of patients with myelofibrosis (MF) marked an important milestone in our understanding of the pathophysiology of MF. This has broadened ... -
Anti-complement treatment in paroxysmal nocturnal hemoglobinuria: where we stand and where we are going
(2014)Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal, non-malignant, hematological disorder characterized by the expansion of hematopoietic stem cells and progeny mature blood cells which are deficient in some surface ... -
Immunological derangement in Hypocellular Myelodysplastic Syndromes
(2014)Hypocellular or hypoplastic myelodysplastic syndromes (HMDS) are a distinct subgroup accounting for 10–15% of all MDS patients, that are characterized by the presence of bone marrow (BM) hypocellularity, various degree of ... -
Molecular Pathogenesis of Myelodysplastic Syndromes
(2014)Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders characterized by inefficient hematopoiesis, hypercellular bone marrow, dysplasia of blood cells and cytopenias. Most patients are diagnosed in ... -
Use of equine pericardium sheet (lyomesh®) as dura mater substitute in endoscopic endonasal transsphenoidal surgery
(2013)Objective: The aim of this study was to describe the use of equine pericardium sheet (Lyomesh®) as dural substitute for sellar reconstruction after endoscopic endonasal transsphenoidal surgery for the removal of pituitary ... -
Pharmacokinetics of remifentanil: a three-compartmental modeling approach
(2013)Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics ... -
Perioperative anaphylactic risk score for risk-oriented premedication
(2013)Basing on the current knowledge, this paper is aimed to review the core characteristics of the most relevant therapeutic agents (steroids and antihistamines), administered to prevent perioperative anaphylaxis. Moreover, ... -
Laparoscopic treatment of a yolk sac tumor. Case report and literature review
(2013)We report the case of a yolk sac tumor of the ovary in a 26 years old woman. The laparoscopic approach and the BEP chemotherapy were fundamental to have a minimally invasive treatment and to preserve fertility -
Ventricular septal defect: the three-dimensional point of view
(2013)This case highlights the clinical usefulness of three-dimensional (3D) echocardiography. The diagnosis of inter-ventricular septal defect associated with aortic regurgitation has been performed in a 50-year-old man using ... -
Genetic test for the channelopaties: useful or less than useful for patients? (part 2.)
(2013)The advanced knowledge about genetic diseases and their mutations has widened the possibility to have a more precise and definitive diagnosis in many patients, but the use of genetic testing is still controversial. Actually, ... -
Shoulder arthroplasty in osteoarthritis: current concepts in biomechanics and surgical technique
(2013)Shoulder arthroplasty is a technically demanding procedure to restore shoulder function in patients with severe osteoarthritis of the glenohumeral joint. The modern prosthetic system exploit the benefits of modularity and ... -
Carotid and vagal body paragangliomas
(2013)Between 1972 and 2012, 25 patients presenting 32 paragangliomas of the neck were observed. Tumor locations included the carotid body (CBTs) in 21 patients and the vagus nerve in 4. Four patients had bilateral CBT and one ... -
OPSI threat in hematological patients
(2013)Overwhelming post-splenectomy infection (OPSI) is a rare medical emergency, mainly caused by encapsulated bacteria, shortly progressing from a mild flu-like syndrome to a fulminant, potentially fatal, sepsis. The risk of ...
