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dc.contributor.authorVicinanza, Paolo
dc.contributor.authorVicinanza, Mariella
dc.contributor.authorCosimato, Vincenzo
dc.contributor.authorTerracciano, Daniela
dc.contributor.authorCancellario, Sergio
dc.contributor.authorMassari, Angelo
dc.contributor.authorDanise, Paolo
dc.contributor.authorSelleri, Carmine
dc.contributor.authorSerio, Bianca
dc.date.accessioned2020-05-26T10:36:39Z
dc.date.available2020-05-26T10:36:39Z
dc.date.issued2017
dc.identifier.citationVicinanza P, Vicinanza M, Cosimato V, Terracciano D, Cancellario S, Massari A, Danise P, Selleri C, Serio B. Mean reticolocyte hemoglobin content index plays a key role to identify children who are carriers of β –thalassemia. Translational Medicine @ UniSa 2017, 17(6): 34-39.it_IT
dc.identifier.issn2239-9747it_IT
dc.identifier.urihttp://www.translationalmedicine.unisa.it/indexit_IT
dc.identifier.urihttp://elea.unisa.it:8080/xmlui/handle/10556/4493
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-2691
dc.description.abstractReticulocyte (r) and red blood cell (RBC) indices provide reliable parameters for screening and monitoring iron deficiency anemia (IDA) patients and β-thalassemia trait (BTT) carriers. The aim of this study is to identify a simple method for use to distinguish β-thalassemia trait carriers from IDA and to evaluate the correlation between BTT genetic mutation and MCV values and new discrimination index for the detection of β-thalassemia trait (DI-BTT). We analyzed CHr, MCHCr, MCVr, RBC, mean cellular hemoglobin concentration (MCHC) and mean cellular volume (MCV) indices among a pediatric population of IDA patients (n=90), βthalassemia trait carriers (n=72) and normal controls (NC) (n=131). Furthermore, to distinguish IDA patients from β-thalassemia trait carriers we evaluated clinical utility of new DI for the detection BTTcarriers, using the following polynomial: (RBC × MCHC × 50/MCV)/CHr. We found that CHr, MCVr and DI-BTT mean values were significantly different between βthalassemia trait carriers and IDA patients. CHr, MCVr and DI-BTT plotting curves showed exclusive distribution in β-thalassemia trait carriers. Moreover, DI-BTT was very accurate in differentiating β-thalassemia trait carriers from IDA patients. All BTT patients showed a heterozygous mutation of the β-globin gene including CD39, IVS1.110, IVS1.6 and IVS2.745, IVS2.1 and IVS1.1. The highest MCV values were displayed by those carrying the IVS1.6 mutation. Conclusions: The simultaneous measurement and plotting of CHr and MCVr indices, as well as the DI-BTT allow to distinguish β-thalassemia carriers from IDA patients.it_IT
dc.format.extentP. 34-39it_IT
dc.language.isoenit_IT
dc.sourceUniSa. Sistema Bibliotecario di Ateneoit_IT
dc.subjectβ-Thalassemiait_IT
dc.subjectReticulocyte indicesit_IT
dc.subjectIron deficiencyit_IT
dc.subjectDI-BTTit_IT
dc.titleMean reticolocyte hemoglobin content index plays a key role to identify children who are carriers of β –thalassemiait_IT
dc.typeArticleit_IT
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