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dc.contributor.authorDe Rosa, Roberta
dc.contributor.authorPolito, Maria Vincenza
dc.contributor.authorBenvenga, Rossella Maria
dc.contributor.authorDe Angelis, Elena
dc.contributor.authorPiscione, Federico
dc.contributor.authorGalasso, Gennaro
dc.date.accessioned2020-05-26T11:13:52Z
dc.date.available2020-05-26T11:13:52Z
dc.date.issued2017
dc.identifier.citationDe Rosa R, Polito MV, Benvenga R, De Angelis E, Piscione F, Galasso G. MicroRNs and cardiovascular diseases: from bench to bedside. Translational Medicine @ UniSa 2017, 17(3): 12-18.it_IT
dc.identifier.issn2239-9747it_IT
dc.identifier.urihttp://www.translationalmedicine.unisa.it/indexit_IT
dc.identifier.urihttp://elea.unisa.it:8080/xmlui/handle/10556/4496
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-2694
dc.description.abstractMicroRNAs (microRNAs or miRs) are small, noncoding RNAs that control gene expression by binding to and repressing specific mRNA target and have emered as powerful regulators of many biological processes. Understanding miRNAs-biology and functions may be pivotal to get a better insight into pathophysiological mechanisms responsible for a large number of morbid conditions and may lay the foundations for the development of novel therapeutic interventions. Moreover, besides their intracellular functions, miRs are present in the human circulation in a remarkably stable cell-free form, and their plasmatic levels have been proposed as biomarkers for several pathological conditions. The present review aims to summarize the current evidences with regard to biological role of miRNAs in cardiovascular system and their involvement in the pathogenesis of cardiovascular diseases including atherosclerosis, heart failure and pathological heart and vascular remodelling and to highlight their potential use as novel biomarkers and as therapeutic targets in cardiac and vascular diseases.it_IT
dc.format.extentP. 12-18it_IT
dc.language.isoenit_IT
dc.sourceUniSa. Sistema Bibliotecario di Ateneoit_IT
dc.subjectMicroRNAsit_IT
dc.subjectAtherosclerosisit_IT
dc.subjectHeart failureit_IT
dc.subjectVascular remodellingit_IT
dc.subjectBiomarkersit_IT
dc.subjectMicroRNAsbased therapeuticsit_IT
dc.titleMicroRNs and cardiovascular diseas es: from bench to besideit_IT
dc.typeArticleit_IT
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