Mostra i principali dati dell'item

dc.contributor.authorMieli-Vergani, Giorgina
dc.contributor.authorVergani, Diego
dc.date.accessioned2013-04-02T15:01:26Z
dc.date.available2013-04-02T15:01:26Z
dc.date.issued2011
dc.identifier.citationMieli-Vergani G, Vergani D. Autoimmune liver disease: news and perspectives. Translational Medicine @ UniSa 2011;1(1):195-212en_US
dc.identifier.issn2239-9747en_US
dc.identifier.urihttp://hdl.handle.net/10556/513
dc.description.abstractAutoimmune liver disorders in childhood include autoimmune hepatitis and autoimmune sclerosing cholangitis. These inflammatory liver disorders are characterised histologically by interface hepatitis, biochemically by elevated transaminase levels and serologically by autoantibodies and increased levels of immunoglobulin G. Autoimmune hepatitis is particularly aggressive in children and progresses rapidly unless immunosuppressive treatment is started promptly. With appropriate treatment 80% of patients achieve remission and long-term survival. Autoimmune sclerosing cholangitis responds to the same treatment used for autoimmune hepatitis in regards to parenchymal inflammation, but bile duct disease progresses in about 50% of cases, leading to a worse prognosis and higher transplantation requirement; it has a high recurrence rate post liver transplant. New strategies aiming at treating unresponsive patients and at curbing specifically the liver autoimmune attack, without provoking unwanted systemic side effects, are being investigated and may be available within the next 5 yearsen_US
dc.format.extentP. 195-212en_US
dc.language.isoenen_US
dc.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dc.subjectAutoimmune hepatitisen_US
dc.subjectAutoimmune sclerosing cholangitisen_US
dc.subjectCorticosteroidsen_US
dc.subjectAzathioprineen_US
dc.subjectCalcineurin inhibitorsen_US
dc.subjectMycophenolate mofetilen_US
dc.subjectUrsodeoxycholic aciden_US
dc.subjectRegulatory T-cellsen_US
dc.titleAutoimmune liver disease: news and perspectivesen_US
dc.typeArticleen_US
 Find Full text

Files in questo item

Thumbnail

Questo item appare nelle seguenti collezioni

Mostra i principali dati dell'item