Area Scienze mediche: Recent submissions
Now showing items 141-160 of 171
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Proteomic profiles of cultured cells stimulated with VEGFs dimers and search for natural compounds angiogenesis inhibitors
(Universita degli studi di Salerno, 2013-06-06)Some members of the vascular endothelial growth factor (VEGF) family, such as VEGF and PlGF, and related receptors (KDR and Flt-1) play a key role in the modulation of angiogenesis, both physiological and pathological. For ... -
Novel Insights into the Biological Effects of the Isoprenoid Derivative N6-Isopentenyladenosine: Involvement of the Metabolic Sensor Ampk in Angiogenesis Inhibition
(Universita degli studi di Salerno, 2014-03-19)N6-isopentenyladenosine (iPA) is a modified adenosine characterized by an isopentenyl chain derived by dimethylallyl pyrophosphate (DMAPP), an intermediate of the metabolic pathway of mevalonate, that is known to be ... -
Molecular pathways involved in metabolic control of CCL5 in adipocytes
(Universita degli studi di Salerno, 2014-03-21)Obesity is a chronic disorder characterized by a tonic low-grade activation of the innate immune system that affects steady-state measures of metabolic homeostasis over time. In addition, obesity is often accompanied ... -
p53 regulates Mevalonate Metabolic pathway
(Universita degli studi di Salerno, 2014-03-14)The mevalonate pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, I provided evidences about genetic and pharmacologic perturbation of p53, which directly influenced ... -
The transcription factor Prep1 regulates adipose tissue functions
(Universita degli studi di Salerno, 2014-03-21)Adipose tissue is crucial for maintaining energy and metabolic homeostasis and its functionality is closely related to the adipocytes differentiation state. Adipogenesis is regulated by several transcription factors. Prep1 ... -
Valutazione dell’induzione di risposta adattativa a mutageni in colture cellulari di mammifero in seguito ad esposizioni a campi elettromagnetici non ionizzanti
(Universita degli studi di Salerno, 2013-02-06)Nell’ambito del progetto di ricerca dal titolo “Valutazione dell’induzione di risposta adattativa a mutageni in colture cellulari di mammifero in seguito ad esposizioni a campi elettromagnetici non ionizzanti” è stato ... -
Le complicanze cardiovascolari nel diabete mellito: studio delle basi molecolari
(Universita degli studi di Salerno, 2013-02-13)Diabetes is characterized by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis. The assumption underlying current clinical treatment is that lowering the level of ... -
The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity
(Universita degli studi di Salerno, 2014-05-21)The thesis entitled “The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity" is divided into three chapters. The title of the thesis clearly reflects the ... -
Biophysical investigation of biomolecules in bio-membrane models
(Universita degli studi di Salerno, 2012-05-30)Many drugs are available for the treatment of systemic or superficial mycoses, but only a limited number of them are effective antifungal drugs, devoid of toxic and undesirable side effects. Therefore there remains an ... -
Studio del ruolo funzionale e caratterizzazione strutturale del cuprocomplesso TFF1-Cu
(Universita degli studi di Salerno, 2012-01-26)The maintenance of gastrointestinal tissue integrity is physiologically essential in the presence of the persistent harassment of microbial flora and injurious agents. Even though the repair of the gastric epithelium may ... -
Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response
(Universita degli studi di Salerno, 2012-03-21)Mapping of the interaction between STAT1 and flavonoids Abstract An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and ... -
Chimica e attività biologica di specie del genere Hypericum
(Universita degli studi di Salerno, 2013-01-14)Lo scopo di questo progetto di ricerca è stato lo studio chimico e biologico di quattro specie del genere Hypericum: H. peforatum L., H. connatum Lam, H. hircinum L., H. perfoliatum L. Nella prima fase, è stato identificato ... -
Sequence analysis in bioinformatics: methodological and practical aspects
(Universita degli studi di Salerno, 2013-04-02)My PhD research activities has focused on the development of new computational methods for biological sequence analyses. To overcome an intrinsic problem to protein sequence analysis, whose aim was to infer homologies in ... -
BAG3 role in cardiomyocytes physiopathology
(Universita degli studi di Salerno, 2013-01-31)The anti-apoptotic protein BAG3 is expressed at high levels in skeletal and cardiac muscle in vivo. Our group recently focused its interest on BAG3 role in myocardiocyte proliferation, survival and response to stressful ... -
Nuove strategie per l'identificazione di molecole ad attività antifungina
(Universita degli studi di Salerno, 2013-01-30)Con l’incremento del numero di persone affette da sindrome da immunodeficienza acquisita (AIDS), dell’uso di terapie immunosoppressive e del numero di pazienti affetti da varie forme di cancro e, dunque, fortemente debilitati ... -
Design and characterization of DPI (dry powder inhaler) for the pulmonary delivery of anti-inflammatory and antibiotic drugs in the treatment of cystic fibrosis disease
(Universita degli studi di Salerno, 2012-03-07)The aim of the present PhD project was to design inhalable powder-based formulations for pharmaceutical products that may improve the treatment of pulmonary diseases, mainly cystic fibrosis, and may be easier for patients ... -
Design, virtual screening and structural studies of new molecules with potential antitumor and antiinflammatory activity
(Universita degli studi di Salerno, 2012-03-30)Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization. The study ... -
Exploring the chemical diversity in marine organisms: new molecules for pharmaceutical applications
(Universita degli studi di Salerno, 2012-02-23)It is increasingly recognized that the oceans preserve a huge number of natural products and novel chemical entities, with biological activities that may be useful in the quest for finding drugs with greater efficacy and ... -
Il sistema adenosinico: principali targets molecolari ad attività anti-tumorale
(Universita degli studi di Salerno, 2012-02-27)L’Adenosina (Ado) è una molecola segnale di origine purinica che esplica le sue funzioni metaboliche mediante quattro recettori metabotropici (A1, A2A, A2B, A3). L’Ado è un autacoide ad attività pleiotropica, che regola ... -
Ruolo della proteina BAG3 nel microambiente tumorale
(Universita degli studi di Salerno, 2012-02-27)Recenti studi hanno dimostrato che il microambiente tumorale subisce numerosi cambiamenti nel corso dello sviluppo del tumore e influenza l’evoluzione e la progressione del cancro. L'ambiente ipossico del tumore stimola ...