Area Scienze mediche: Recent submissions
Now showing items 61-80 of 152
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Rischio clinico, gestione del rischio e sue implicazioni. Un aspetto della medicina traslazionale
(Universita degli studi di Salerno, 2017-06-05)This thesis is based on the awareness that prevention in the ethical and vocational training of health workers is extremely important, above all the one concerned with the clinical risk as well as a competent and intelligent ... -
Role of TFF1 in tumor progression
(Universita degli studi di Salerno, 2017-03-31)Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ... -
NMR-based metabolomic analysis of biological fluids to monitor relevant unsolved diseases
(Universita degli studi di Salerno, 2017-03-30)Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle, environment, stimuli and genetic ... -
Bioactives from agricultural food by-products: application in food and health
(Universita degli studi di Salerno, 2017-04-04)Agriculture and agri-food industry produce a large amount of residues in non-edible portions from cultivation and processing of crops. These wastes, considered by-products, give serious environment damage, if not properly ... -
Role of Annexin A1 in tumor progression
(Universita degli studi di Salerno, 2016-10-06)Annexin 1 (ANXA1) is a multifunctional protein of 37 kDa, and represents the first characterized member of the annexin superfamily, so called since their main property is to bind (i.e. to annex) cell membranes in Ca2+-dependent ... -
Studio dei meccanismi molecolari alla base dell’azione dei microRNA in processi patologici
(Universita degli studi di Salerno, 2016-05-10)My research project concerns the study of the molecular mechanisms involving microRNAs (miRNAs) in pathological processes such as tumors and cardiovascular diseases. miRNAs are small non-coding RNAs (sncRNAs) acting by ... -
Design, synthesis, biological studies of new mitochondrial modulators improving neurological deficits in experimental models of Huntington's disease
(Universita degli studi di Salerno, 2017-03-22) -
Techniques of proteomic analysis as tools for studies in biomedical field
(Universita degli studi di Salerno, 2017-03-24)It is known that prenatal exposure to pollutants and particularly heavy metals can have long term damaging consequences on infants, due to their accumulation in-body. Since the 1990s, ten million tonnes of waste have been ... -
In vitro and in vivo study of cannabinoids as modulators of Wnt/β-catenin pathway in human colorectal cancer
(Universita degli studi di Salerno, 2017-03-23)Colorectal cancer (CRC) is the second most common cause of cancer death. Molecular events in CRC has been extensively studied and several data suggest that Wnt/β-catenin signaling deregulation play a pivotal role in ... -
Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents
(Universita degli studi di Salerno, 2017-03-22)One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the ... -
Studio del meccanismo d’azione e dei parametri strutturali di nuovi materiali ad azione antimicrobica
(Universita degli studi di Salerno, 2017-03-28)The increased demand of new and more effective materials able to reduce and prevent microbiological contamination is one of the great challenges of scientific research. In the last decade, the use of antimicrobial polymers ... -
Identification of new genetic alterations and potential biomarkers in papillary thyroid carcinoma
(Universita degli studi di Salerno, 2016-05-24)Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignant neoplasia. Oncogene activation occurs in more than 70% of the cases. BRAF mutations occur in about 40% of PTCs, whereas RET rearrangements ... -
Regolazione post-trascrizionale dell’espressione del recettore dell’urochinasi
(Universita degli studi di Salerno, 2016-12-14)The urokinase type plasminogen activator (uPAR) is a three domain GPI-anchored cell surface receptor. uPAR expression is strongly up-regulated and represents a negative prognostic factor in various tumors, including ... -
Neurodegeneration in Chronic Kidney Disease: role of neuroinflammation and uremic toxins
(Universita degli studi di Salerno, 2017-03-28)Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ... -
Design and synthesis of peptides involved in the inhibition of influenza virus infection
(Universita degli studi di Salerno, 2017-03-28)The main purpose of the present research project was the identification of peptide capable of exercising potent anti-influenza activity. We identified bovine lactoferrin (bLf) as drug target, a multifunctional glycoprotein ... -
Design and synthesis of new integrase inhibitors
(Universita degli studi di Salerno, 2017-03-28)The viral enzyme integrase (IN) is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents an important target for the development of new antiretroviral drugs. In this PhD project, we ... -
Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)
(Universita degli studi di Salerno, 2017-03-27)JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires ... -
Chronotherapeutic Drug Delivery in Early Morning Pathologies: Design and Production of new NSAIDs/SAIDs polysaccharide-based systems
(Universita degli studi di Salerno, 2017-03-28)The major technological challenge encountered when formulating new dosage forms is to find a way to adapt drug release kinetics to specific clinical requirements, with the aim to enhance the therapeutic action of both new ... -
Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis
(Universita degli studi di Salerno, 2017-03-28)Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as ... -
BAG3 extracellulare: target cellulari e molecolari
(Universita degli studi di Salerno, 2016-07-12)Bcl-2-associated athanogene 3 (BAG3) belongs to the family of co-chaperone proteins that interact with the heat shock protein 70 (Hsp70) and is involved in a number of cellular processes including proliferation and apoptosis. ...