Area Scienze mediche
Collezioni in questa sotto-comunità
Immissioni Recenti
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Design, synthesis and pharmacological evaluation of new enzyme inhibitors
(Universita degli studi di Salerno, 2023-04-13)My PhD research plan relates to the exploration of the structural requirements for the modulation of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part of my doctoral ... -
Analytical procedures for the safety assessment of dietary supplements and botanicals
(Universita degli studi di Salerno, 2023-04-06)The consumption of dietary supplements and botanicals is not always safe and free of potential health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a group of plant secondary ... -
Analytical procedures for the safety assessment of dietary supplements and botanicals
(Universita degli studi di Salerno, 2023-04-06)The consumption of dietary supplements and botanicals is not always safe and free of potential health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a group of plant secondary ... -
Bioprospecting of plants from Campania region to promote the sustainable use of biodiversity
(Universita degli studi di Salerno, 2023-04-12)This research aimed to chemical-biological study of plant and fungal species from inland areas of Campania Region, typically used in preparations for medicinal purposes or food traditional recipes. In the preliminary ... -
Molecular mechanisms of TFF1-Helicobacter cross-talk
(Universita degli studi di Salerno, 2023-04-18)Helicobacter pylori is one of the most important pathogenic bacteria associated with various gastric diseases, including cancer. This pathogen induces an acute mucosal inflammatory response and, if not eradicated, it ... -
Development of novel anticancer compounds directed towards promising therapeutic targets
(Universita degli studi di Salerno, 2023-04-19)Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant activity in proteins involved in this ... -
Targeted and untargeted proteomic approaches to disclose small molecules interactome
(Universita degli studi di Salerno, 2023-04-24)The identification of natural products and synthetic compounds target proteins is pivotal to understand their mechanism of action for the development of molecular probes and/or potential drugs. Functional proteomics is ... -
Alginate hydrogels in drug delivery: from physico- chemical to technological studies of a promising polysaccharide for 3D printing applications.
(Universita degli studi di Salerno, 2022-10-20)Focusing the attention on the futuristic concept of personalized medicine, the Ph.D. project aimed to demonstrate the potentialities of hydrogels as a versatile feed material for the semi solid extrusion 3D printing ... -
Role of CD73 in patients with advanced melanoma treated with anti-PD-1 agents
(Universita degli studi di Salerno, 2022-04-04)The treatment of metastatic melanoma was revolutionized by the approval of inhibitors of immune-checkpoints, including antibodies targeting the programmed cell death protein 1 (PD- 1), such as nivolumab and pembrolizumab. ... -
Innovative technological strategies for the production of in situ gelling powders containing active biomolecules for wound healing
(Universita degli studi di Salerno, 2022-05-02)The aim of this Ph.D. project is the development of novel topical formulations for the treatment of various wounds by innovative technologies (micro and nano spray drying). The specific objective is the production of a ... -
Circulating sortilin level as a potential biomarker for endothelial dysfunction and hypertension
(Universita degli studi di Salerno, 2022-03-16)Sortilin has been positively correlated with vascular disorders in humans. Previous studies showed that sortilin promotes activation of acid sphingomyelinase (ASMase) and subsequently induces an increase of nicotinamide ... -
Development of analytical strategies for phytochemical investigation of «superfoods», with particular attention to Botanicals.
(Universita degli studi di Salerno, 2022-04-27)There is a great attention to functional foods exerting health benefits. In this frame the claim ‘superfood’ to characterize products with high nutritional value and bioactive phytochemicals is more and more used. In ... -
Proteomic investigation of the impact of Cannabidiolic acid on Eukaryotic Translation complex in glioblastoma
(Universita degli studi di Salerno, 2023-04-12)Phytocannabinoids, the major secondary metabolites of cannabis plants, exert a wide range of biological activities. The present work was focused on investigating the mechanism of action of cannabidiolic acid (CBDA) in ... -
Post-transcriptional gene regulatory networks in chronic airway inflammation: role of RNA-binding proteins
(Universita degli studi di Salerno, 2020-05-06)Background. RNA-binding proteins (RBPs) play a key role in post-transcriptional gene regulation (PTGR) of genes involved in numerous biological processes. These proteins act through the binding to specific cis-elements ... -
Design and production of personalised medicines via innovative 3D printing technologies
(Universita degli studi di Salerno, 2021-05-04)The perspective of personalized therapies in recent years is projecting the community towards a rampant hankering for individualization of healthcare. Paramount is the necessity of re-organizing the healthcare services ... -
Opportunità e rischi della longevità. Aspettative presenti e future dal punto di vista epidemiologico, ecologico, medico e sociale, soprattutto sulla base dell’esperienza dei medici
(Universita degli studi di Salerno, 2021-06-15)Longevity is considered one of the greatest achievements of modern society. "Staying young forever" seems to be the new trend: Downgrading (i.e. being younger today than at the same age in the past) shows that there are ... -
Application of Artificial Neural Networks to the design and optimization of superhydrophobic coatings
(2021-05-19)Recently, considerable attention has been devoted to developing superhydrophobic surfaces due to their advantageous antimicrobial and self-cleaning properties. While significant effort has been devoted to their fabrication, ... -
Development and Evaluation of Innovative Stationary Phases for Separation of Pharmaceuticals, Metabolites and Biocompounds
(Universita degli studi di Salerno, 2020-09-18)Biofluids are typical complex matrices representing a source of potential biomarkers, but often require high demands in sample preparation prior to analysis. With this purpose, several techniques have been developed ... -
Development of a versatile screening platform for the identification of small-molecule ligands for reader proteins of the post-translational methylation
(Universita degli studi di Salerno, 2021-06-25)Covalent Post Translational Modifications (PTMs) of histone proteins are introduced and removed by the ‘writer’ and ‘eraser’ enzymes, respectively. These modifications are recognized by highly specific binding domains, ... -
Clinical characterization, genetic screening and genotype-phenotype associations in cerebellar and brainstem congenital defects
(Universita degli studi di Salerno, 2020-10-01)Cerebellar and brainstem congenital defects (CBCDs) represent a wide spectrum of malformative disorders resulting from abnormal development of midbrain-hindbrain and characterised by high clinical and genetic heterogeneity. ...