Please use this identifier to cite or link to this item: http://elea.unisa.it:8080/xmlui/handle/10556/1379
Title: Discovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challenges
Authors: Palladino, Carmela
Bruno, Benedetto
Boccadoro, Mario
Keywords: MGUS
Monoclonal gammopathy of undetrmined significance
Non malignant haematological disorders
Pre-malignant haematological neoplasms
Issue Date: 2014
Citation: Palladino C, Bruno B, and Boccadoro M. Discovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challenges. Translational Medicine @ UniSa 2014;8(3):12-18
Abstract: Monoclonal gammopathy of undetermined significance (MGUS) is a non malignant plasma cell disorder with a relatively low risk of progression to Multiple Myeloma (MM) and to related Plasma cells disordes (lymphoplasmacellular neoplasms, Waldenstrom Macroglobulinemia or light chain amyloidosis). It is a quite common finding, especially in the population above the age of 50 and it can also present in association with many non malignant conditions. Differential diagnosis of symptomatic and asymptomatic forms is the determinant for starting therapy. Over the last few years many advances in the understanding of the biology of MGUS, together with large epidemiological studies, allowed to define risk models to estimate the risk of progression to MM according to MGUS isotype and, more recently, to peculiar flow cytometry findings. The goal of many recent studies aims at evaluating individual patients and their overall risk of progression, the detection of early signs of progression and the development of timely treatment strategies.
URI: http://hdl.handle.net/10556/1379
http://dx.doi.org/10.14273/unisa-228
ISSN: 2239-9747
Appears in Collections:Translational Medicine @ UniSa. Vol.8 (jan.-mar. 2014)

Files in This Item:
File Description SizeFormat 
Palladino C, Bruno B, Boccadoro M. Discovering the meaning of monoclonal gammopathy of undetermined significance.pdfarticolo di rivista239,82 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.