Please use this identifier to cite or link to this item: http://elea.unisa.it:8080/xmlui/handle/10556/1384
Title: Current Concepts on Diagnosis and Treatment of Mastocytosis
Authors: Magliacane, Diomira
Parente, Roberto
Triggiani, Massimo
Keywords: Mastocytosis
Issue Date: 2014
Citation: Magliacane D, Parente R, and Triggiani M. Current Concepts on Diagnosis and Treatment of Mastocytosis. Translational Medicine @ UniSa 2014;8(8):65-74
Abstract: Mastocytosis is a heterogeneous group of disorders characterized by a clonal proliferation and accumulation of mast cells in one or more organ, primarily in the skin and bone marrow. The clinical spectrum of the disease varies from relatively benign forms with isolated skin lesions to very aggressive variants with extensive systemic involvement and poor prognosis. The growth and proliferation of clonal mast cells is caused by an activating mutation of the tyrosine kinase receptor Kit for Stem Cell Factor, the main growth factor for mast cells. Clinical symptoms are related to mast-cell mediator release, to the tissue mast cell infiltration or both. The degree of infiltration and cell activation determines the highly variable clinical and morphological features. Current treatment of mastocytosis includes symptomatic, antimediator drugs and cytoreductive targeted therapies.
URI: http://hdl.handle.net/10556/1384
http://dx.doi.org/10.14273/unisa-233
ISSN: 2239-9747
Appears in Collections:Translational Medicine @ UniSa. Vol.8 (jan.-mar. 2014)

Files in This Item:
File Description SizeFormat 
Magliacane D, Parente R, Triggiani M. Current Concepts on Diagnosis and Treatment of Mastocytosis.pdfarticolo di rivista485,97 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.