Please use this identifier to cite or link to this item: http://elea.unisa.it:8080/xmlui/handle/10556/1385
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dc.contributor.authorD'Arena, Giovanni-
dc.contributor.authorMusto, Pellegrino-
dc.date.accessioned2014-06-04T10:47:55Z-
dc.date.available2014-06-04T10:47:55Z-
dc.date.issued2014-
dc.identifier.citationD’Arena G, Musto P. Monoclonal B-cell lymphocytosis. Translational Medicine @ UniSa 2014;8(9):75-79en_US
dc.identifier.issn2239-9747en_US
dc.identifier.urihttp://hdl.handle.net/10556/1385-
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-234-
dc.description.abstractMonoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 109/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, cytopenias or autoimmune diseases. It is found in approximately 3-12% of normal persons depending on the accuracy of analytical techniques applied. According to the immunophenotypic profile of clonal B-cells, the majority of MBL cases (75%) are classified as chronic lymphocytic leukemia (CLL)-like. This form may progress into CLL at a rate of 1–2% per year. It is thought that CLL is always preceded by MBL. The remaining MBL cases are defined as atypical CLL-like (CD5+/CD20bright) and CD5- MBL. The MBL clone size is quite heterogenous. Accordingly, two forms of MBL are identified: i) high-count, or ‘clinical’ MBL, in which an evidence of lymphocytosis (<5 x 109/L clonal B-cells) is seen, and ii) a low-count MBL, in which a normal leukocyte count is found and that is identified only in population-screening studies. Both forms of MBL may carry the cytogenetic abnormalities that are the hallmark of CLL, including 13q-, 17p- and trisomy 12. Consistent with the indolent phenotype of this condition, genetic lesions, such as TP53, ATM, NOTCH1 and SF3B1 mutations, usually associated with high-risk CLL, are rarely seen. Overall, no prognostic indicator of evolution of MBL to overt CLL has been found at present time. However, taking into account this possibility, a clinical and lab monitoring (at least annually), is recommended.en_US
dc.format.extentP. 75-79en_US
dc.language.isoenen_US
dc.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dc.subjectMonoclonal B-cell lymphocytosisen_US
dc.subjectChronic lymphocytic leukemiaen_US
dc.subjectDiagnostic criteriaen_US
dc.subjectManagementen_US
dc.titleMonoclonal B-cell lymphocytosisen_US
dc.typeArticleen_US
Appears in Collections:Translational Medicine @ UniSa. Vol.8 (jan.-mar. 2014)

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