Utilizza questo identificativo per citare o creare un link a questo documento: http://elea.unisa.it/xmlui/handle/10556/1474

Autore:	Ciambelli, Paolo Vittoria, Vittoria
Abstract:	The technical parameters for electrospinning solutions of biodegradable polymers poly(ε-caprolactone), poly(lactic acid) and their composites with active molecules were defined and set up. A trial-and-error approach has been employed by varying solution properties and processing parameters to obtain uniform defect-free fibers. Amoxicillin drug was intercalated in layered double hydroxide nanoparticles by coprecipitation and then the modified nanohybrid was successfully encapsulated at different concentrations into poly(ε-caprolactone) matrix by the electrospinning technique. Non-woven fibrous mats were fabricated and characterized in terms of morphology, in vitro release and antibacterial properties. Blends of poly(lactic acid) and poly(ε-caprolactone), loaded with different amounts of amoxicillin were electrospun to investigate the release behaviour and obtain a controlled and tuneable release. Morphology and thermal behaviour were found dependent on the component ratio as well as on the incorporated drug amount. [edited by author]
Descrizione:	2011 - 2012
È visualizzato nelle collezioni:	Scienza e tecnologie per l’industria chimica, farmaceutica e alimentare

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