Please use this identifier to cite or link to this item: http://elea.unisa.it:8080/xmlui/handle/10556/1474
Title: Innovative processes for the production of new nanocomposite materials by electrospinning technique
Authors: Valarezo Valdez, Benito Eduardo
Ciambelli, Paolo
Vittoria, Vittoria
Keywords: Electrospinning
Composite nanofibers
Polymer concentration
Drug delivery
Fibers
Issue Date: 19-Mar-2013
Publisher: Universita degli studi di Salerno
Abstract: The technical parameters for electrospinning solutions of biodegradable polymers poly(ε-caprolactone), poly(lactic acid) and their composites with active molecules were defined and set up. A trial-and-error approach has been employed by varying solution properties and processing parameters to obtain uniform defect-free fibers. Amoxicillin drug was intercalated in layered double hydroxide nanoparticles by coprecipitation and then the modified nanohybrid was successfully encapsulated at different concentrations into poly(ε-caprolactone) matrix by the electrospinning technique. Non-woven fibrous mats were fabricated and characterized in terms of morphology, in vitro release and antibacterial properties. Blends of poly(lactic acid) and poly(ε-caprolactone), loaded with different amounts of amoxicillin were electrospun to investigate the release behaviour and obtain a controlled and tuneable release. Morphology and thermal behaviour were found dependent on the component ratio as well as on the incorporated drug amount. [edited by author]
Description: 2011 - 2012
URI: http://hdl.handle.net/10556/1474
http://dx.doi.org/10.14273/unisa-317
Appears in Collections:Scienza e tecnologie per l’industria chimica, farmaceutica e alimentare

Files in This Item:
File Description SizeFormat 
tesi_BE_Valarezo_Valdez.pdftesi di dottorato4,67 MBAdobe PDFView/Open
abstract_in_inglese_BE_Valarezo Valdez.pdfabstract in inglese a cura dell'autore152,8 kBAdobe PDFView/Open
abstract_in_italiano_BE_Valarezo_Valdez.pdfabstract in italiano a cura dell'autore217,99 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.