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dc.contributor.authorPesca, Mariasabina-
dc.date.accessioned2014-09-15T09:07:22Z-
dc.date.available2014-09-15T09:07:22Z-
dc.date.issued2013-06-06-
dc.identifier.urihttp://hdl.handle.net/10556/1515-
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-358-
dc.description2010 - 2011en_US
dc.description.abstractSome members of the vascular endothelial growth factor (VEGF) family, such as VEGF and PlGF, and related receptors (KDR and Flt-1) play a key role in the modulation of angiogenesis, both physiological and pathological. For this reason they are considered valid therapeutic targets. Anti-angiogenesis therapy, despite the scientific efforts and promising results, is still suffering of some limitations. In the attempt to produce a research that can facilitate the future development of new antiangiogenic therapy strategies, we realized these goals: 1) carry out an expression proteomic study of cell coltures, after their treatment with some dimers of VEGF family; 2) identify new natural compounds able to inhibit the axis of interaction VEGF/Flt-1 and PlGF/Flt-1. We used gel-based proteomics to detect the differentially expressed proteins by VEGF, PlGF and VEGF/PlGF, in HUVECs and HEK-293-hFlt-1. Gels variability was also determined by principal component analysis (PCA)... [edited by Author]en_US
dc.language.isoenen_US
dc.publisherUniversita degli studi di Salernoen_US
dc.subjectProteomicen_US
dc.subjectVEGFen_US
dc.subjectNatural compoundsen_US
dc.titleProteomic profiles of cultured cells stimulated with VEGFs dimers and search for natural compounds angiogenesis inhibitorsen_US
dc.typeDoctoral Thesisen_US
dc.subject.miurCHIM/09 FARMACEUTICO TECNOLOGICO APPLICATIVOen_US
dc.contributor.coordinatoreDe Tommasi, Nunziatinaen_US
dc.description.cicloX n.s.en_US
dc.contributor.tutorDal Piaz, Fabrizioen_US
dc.contributor.tutorDe Falco, Sandroen_US
dc.identifier.DipartimentoFarmaciaen_US
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