Please use this identifier to cite or link to this item:
http://elea.unisa.it/xmlui/handle/10556/1636
Title: | Designing in-vitro systems to simulate the in-vivo permeability of drugs |
Authors: | Cascone, Sara Lamberti, Gaetano Titomanlio, Giuseppe |
Keywords: | Permeability;Artificial membranes;Franz cell;In-vitro/in-vivo correlations;Stokes radius;Oral delivery |
Issue Date: | 2014 |
Citation: | Cascone S, Lamberti G, Titomanlio G. Designing in-vitro systems to simulate the in-vivo permeability of drugs. Translational Medicine @ UniSa 2014;10(5):14-21 |
Abstract: | In this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several active molecules have been evaluated across a synthetic membrane. The permeability of these drugs measured through the artificial membrane were successfully correlated to their in-vivo permeability. The relationship with in-vivo permeability was derived, and then a rule to design systems to simulate the intestinal absorption was proposed to reduce the need for expensive and ethical problematic in-vivo measurements |
URI: | http://hdl.handle.net/10556/1636 http://dx.doi.org/10.14273/unisa-440 |
ISSN: | 2239-9747 |
Appears in Collections: | Translational Medicine @ UniSa. Volume 10 (sept.-dec. 2014) |
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File | Description | Size | Format | |
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Cascone_Lamberti_Titomanlio_Designing_in-vitro_systems_to_simulate_the_in-vivo_permeability_of_drugs.pdf | articolo di rivista | 421,26 kB | Adobe PDF | View/Open |
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