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Title: Fluorescence-based sensors for the detection of biologically and environmentally relevant molecules
Authors: Mirra, Silvia
Guerra, Gaetano
Pellecchia, Claudio
Mazzeo, Mina
Canters, Gerard
Keywords: Fluorescent
Issue Date: 15-Mar-2016
Publisher: Universita degli studi di Salerno
Abstract: Hydrogen sulfide (H2S) has been known for long time as a toxic molecule in biological systems. More recent studies have shown that mammals can produce H2S in a controlled fashion, suggesting that it’s important in maintaining normal physiology. In particular, recent efforts are mostly devoted to implement sensitive and selective detection techniques to monitor the distribution and function of this molecule in complicated biological systems. Depending on the mechanism by which the recognition event occurs there are three main approaches in the literature. 1) Azide-to-amine reduction, 2) Nucleophilic addition and 3) Copper displacement. The idea behind this doctoral thesis project is based on a different approach: a coordinative mechanism. In this way one may, in principle, be able to remove H2S from the metal center of the sensor and ensure a reversible H2S binding process. This would be advantageous for practical sensing applications allowing reusability of the sensing device... [edited by author]
Description: 2014 - 2015
Appears in Collections:Chimica

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abstract in inglese S. Mirra.docxabstract in inglese a cura dell'autore190,14 kBMicrosoft Word XMLView/Open

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