• Advanced applications of robotics in digestive surgery 

    Patriti, Alberto; Addeo, Pietro; Buchs, Nicolas; Casciola, Luciano; Morel, Philippe (2011)
    Laparoscopy is widely recognized as feasible and safe approach to many oncologic and benign digestive conditions and is associated with an improved early outcome. Robotic surgery promises to overcome intrinsic limitations ...
  • Design and synthesis of new polycyclic compounds with potential anticancer activity 

    Musella, Simona (Universita degli studi di Salerno, 2011-02-21)
    p53 is best known as a tumor suppressor that transcriptionally regulates, in response to cellular stresses such as DNA damage or oncogene activation, the expression of various target genes that mediate cell-cycle arrest, ...
  • Role of CD73 - A2A/A2B receptors axis in cancer 

    Sorrentino, Claudia (Universita degli studi di Salerno, 2018-04-05)
    The adenosinergic pathway plays a critical role in cancer development and progression, as well as in drug resistance to chemotherapy and/or targeted-therapy. The goal of this PhD thesis was to investigate and fully ...
  • Structural studies, design, identification and biological evaluation of bioactive compounds settore 

    Cantone, Vincenza (Universita degli studi di Salerno, 2016-04-04)
    Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ...
  • To NFkB or not to NFkB: the dilemma on how to inhibit a cancer cell fate regulator 

    Sorriento, Daniela; Illario, Maddalena; Finelli, Rosa; Iaccarino, Guido (2012)
    Nuclear factor B (NFB) is a transcription factor that plays an important role in carcinogenesis as well as in the regulation of inflammatory response. NFB is constitutively expressed in tumours where it induces ...