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New applications of Ester/Amide surrogates in organic synthesis
(Universita degli studi di Salerno, 2021-04-22)
Masked esters/amides are scaffolds endowed with a great potential in the field of organic synthesis. This PhD
project has been conceived, in the context of non-covalent organocatalysis, with the aim to exploit unsaturated ...
Design, synthesis and biological evaluation of small molecules able to interact with macromolecular targets involved in tumor pathology
(Universita degli studi di Salerno, 2021-05-06)
Inflammation and cancer are two complex pathological processes that exploit several molecular actors. The identification of new platforms able to interfere with biological targets placed at the crossroads of these two ...
New perspectives in phase transfer catalysis
(Universita degli studi di Salerno, 2020-02-11)
The increasing demand for the stereoselective synthesis of bioactive compounds in both industrial and academic research has led to the rapid development of a variety of diastereo- and enantio-selective processes using phase ...
Development of eco-sustainable methodologies for innovative materials inspired by cellulose fibers
(Universita degli studi di Salerno, 2021-04-28)
This PhD is an “Industrial-PhD”, carried out in collaboration between University of Basilicata and
LUCART S.p.A (Porcari, Lucca, Italy), in that case with the plant located at Avigliano (Potenza, Italy).
The scholarship ...
Heterocyclic architecture for the synthesis of anti-HIV protease and anti-cancer compounds
(Universita degli studi di Salerno, 2020-02-14)
Introduction of heterocycle moieties in a bioactive molecule can have important effects on physicochemical and pharmacological properties, because of their chemical stability, their structural rigidity and due to the ...
Chiral Bioactive Cyclopeptoids: Concepts and Purposes
(Universita degli studi di Salerno, 2020-02-09)
Peptides are an endless source of inspiration for medicinal chemistry, as these biomacromolecules regulate a number of biological activities, acting as hormones, neurotransmitters, signalling molecules and so on. They show ...
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform
(Universita degli studi di Salerno, 2020-10-24)
The identification of natural products (NPs) target proteins is pivotal to understand their
mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years,
affinity chromatogra ...
Synthesis of new water reducer superplasticizers for building materials
(Universita degli studi di Salerno, 2021-07-18)
This industrial PhD project is focused on the development of new additives called
Superplasticizers (SPs) that are particularly interesting for the engineering of
construction field. These attracting molecules are organic ...
Stereoselectivity in asymmetric processes and molecular assemblies
(Universita degli studi di Salerno, 2020-02-19)
The aim of this thesis was to explore different areas of organic chemistry in which the
stereocontrol in the design of chemical processes and/or molecular assemblies is necessary.
Therefore, the stereoselectivity in ...
Bioinspired supramolecular catalysis in nanoconfined space
(Universita degli studi di Salerno, 2021-04-17)
The nanoconfinement in Nature is the key for the selectivity of enzymatic reactions: when the substrates are confined in the enzyme pocket, overconcentration and proximity effects promote the reaction in very efficient and ...