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Chiral organocatalysts mediated asymmetric oxyfunctionalization and tandem reaction
(Universita degli studi di Salerno, 2015-03-13)
Asymmetric organocatalysis is a new rapidly growing field whose huge potential is becoming more and more evident.This PhD project has been conceived and developed in the context of non-covalent organocatalysis.
The aim ...
Design, virtual screening and structural studies of new molecules with potential antitumor and antiinflammatory activity
(Universita degli studi di Salerno, 2012-03-30)
Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization.
The study ...
In vitro and in cell functional proteomics on natural compounds
(Universita degli studi di Salerno, 2014-04-24)
Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification ...
Design, synthesis and biological activity of new target selective antitumoral agents
(Universita degli studi di Salerno, 2018-04-05)
Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ...
Synthesis and properties of new macrocyclic derivates
(Universita degli studi di Salerno, 2019-02-06)
Effect of thermo wood modification and polyoxometalates catalysts on yield and extractives composition
(Universita degli studi di Salerno, 2019-02-06)
The aims of this work were to investigate the impact of the heat treatment on
the chemical composition (holocellulose, lignin and extractives) of different
wood species, to characterise and quantify wood extractives and ...
Computational chemistry techniques for the design and the synthesis of molecules with anti-inflammatory and anti-tumor activity
(Universita degli studi di Salerno, 2019-06-18)
In the last few years, computational chemistry has played an important role in disclosing novel compounds with relevant biological activity. Inflammation and cancer processes have been recently linked, and the identification ...
Enantioselective construction of new heterocyclic scaffolds via organocatalyzed cascade reactions
(Universita degli studi di Salerno, 2019-02-04)
Chirality plays a vital role in human daily life. After the famous but tragic case regarding the Thalidomide, Food and Drug Administration (FDA) gave a guide in relation to the submission of new drug applications... [edited ...
Pharmacological potential and phytochemical profile of three unexplored medicinal plants
(Universita degli studi di Salerno, 2019-02-06)
Nature is a wide source of biologically active compounds investigated with the
purpose to be used as drugs due to their biological activity and also useful in
pharmaceutical discovery and drug design. Nowadays, medicinal ...