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Novel macrocyclic systems in asymmetric phase-transfer catalysis
(2017-02-27)
In the great realm of organic synthesis, phase-transfer catalysis (PTC) is a well recognized methodology which plays a key role both in industry and academia research. This process involves reactions that take place between ...
Computational chemistry techniques for the design and the synthesis of molecules with anti-inflammatory and anti-tumor activity
(2019-06-18)
In the last few years, computational chemistry has played an important role in disclosing novel compounds with relevant biological activity. Inflammation and cancer processes have been recently linked, and the identification ...
Effect of thermo wood modification and polyoxometalates catalysts on yield and extractives composition
(2019-02-06)
The aims of this work were to investigate the impact of the heat treatment on
the chemical composition (holocellulose, lignin and extractives) of different
wood species, to characterise and quantify wood extractives and ...
Pharmacological potential and phytochemical profile of three unexplored medicinal plants
(2019-02-06)
Nature is a wide source of biologically active compounds investigated with the
purpose to be used as drugs due to their biological activity and also useful in
pharmaceutical discovery and drug design. Nowadays, medicinal ...
Enantioselective construction of new heterocyclic scaffolds via organocatalyzed cascade reactions
(2019-02-04)
Chirality plays a vital role in human daily life. After the famous but tragic case regarding the Thalidomide, Food and Drug Administration (FDA) gave a guide in relation to the submission of new drug applications... [edited ...
Design, synthesis and biological activity of new target selective antitumoral agents
(2018-04-05)
Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ...
In vitro and in cell functional proteomics on natural compounds
(2014-04-24)
Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification ...
Calixarene based catalytic systems
(2018-02-22)
Catalysis is the essence of chemistry as it provides useful tools to make and brake chemical bonds. As nature has been a guide to many scientists, it’s no surprise that in the field of catalysis enzymes were a source of ...
Synthesis and properties of new macrocyclic derivates
(2019-02-06)
This PhD thesis is concerned with the design, synthesis and the characterization of new macrocyclic derivatives. Development of new macrocyclic compounds is a particularly interesting because they can involve like building ...