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Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery 

Feoli, Alessandra (2016-04-20)
The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, ...
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Design and synthesis of bioactive small molecules by traditional and innovative methods 

Ciaglia, Tania (2018-03-28)
My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ...
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Structural investigation of gp36-MPER in membrane mimicking systems 

Stillitano, Ilaria (2019-05-07)
FIV is a lentivirus that resembles the Human Immunodeficiency Virus (HIV). The lentiviral envelope glycoproteins (gp41 in HIV and gp36 in FIV) mediate virus entry by interacting with specific receptors present at the cell ...
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Design, synthesis and biological studies of novel heterocyclic compounds as anticancer drugs 

Botta, Antonio (2015-04-24)
Heterocyles are an essencial class of molecules, assuming a role in many aspect of our life. Indeed heterocyclic nucleus is a common feature of several biomolecule and bioactive compounds including agrochemical products ...
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Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs) 

Rescigno, Donatella (2018-04-20)
Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...
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AuthorBalzano, Amodio Luca (1)Botta, Antonio (1)Bruno, Ferdinando (1)Caporale, Angelamaria (1)Ciaglia, Tania (1)Cianciulli, Agostino (1)Di Cristo, Francesca (1)Di Marino, Sara (1)Di Sarno, Veronica (1)Feoli, Alessandra (1)... View MoreSubject
CHIM/08 CHIMICA FARMACEUTICA (25)
Epigenetics (4)NMR (2)5-lipoxygenase (1)Activity (1)Anti-inflamatory activity (1)Anticancer (1)Antioxidant (1)Antitumor agents (1)Arbidol (1)... View MoreDate Issued2017 (7)2015 (6)2016 (4)2011 (2)2018 (2)2012 (1)2013 (1)2014 (1)2019 (1)Has File(s)Yes (25)
EleA themes by Ugsiba