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Now showing items 21-25 of 25
Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery
(2016-04-20)
The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, ...
Design and synthesis of bioactive small molecules by traditional and innovative methods
(2018-03-28)
My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ...
Structural investigation of gp36-MPER in membrane mimicking systems
(2019-05-07)
FIV is a lentivirus that resembles the Human Immunodeficiency Virus (HIV). The lentiviral envelope glycoproteins (gp41 in HIV and gp36 in FIV) mediate virus entry by interacting with specific receptors present at the cell ...
Design, synthesis and biological studies of novel heterocyclic compounds as anticancer drugs
(2015-04-24)
Heterocyles are an essencial class of molecules, assuming a role in many aspect of
our life. Indeed heterocyclic nucleus is a common feature of several biomolecule and
bioactive compounds including agrochemical products ...
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(2018-04-20)
Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...