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Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...
Synthesis and properties of linear and cyclic peptoids
(2012-03-26)
Le strutture e le attività metaboliche di tutte le cellule si basano su una vasta gamma di molecole comprendenti: amminoacidi, carboidrati, lipidi e nucleotidi, insieme alle forme polimeriche di questi composti. Ognuna di ...
Design e sintesi di analoghi delle azumammidi, potenti inibitori degli enzimi HDACs
(2011-03-07)
Le azumammidi sono cinque ciclopeptidi di origine marina, isolate nel 2003 da
Fusetani et al dalla spugna Mycale izuensis e brevettate dalla Yamanouchi Pharmaceutical.
L'interesse destato da questi metaboliti secondari è ...
Chemical proteomics on ligand protein
(2011-03-18)
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ...
Enzymatic synthesis of macrolactones
(2011-02-24)
Macrolactones are a large and structurally diverse class of compounds. Natural products having a
macrolactone structure have been isolated from many natural sources such as plants, insects,
marine organism and bacteria. ...
Stereoselective carbon-carbon and carbon-heteroatom bond formation mediated by bifunctional organocatalysts
(2013-01-30)
This PhD work describes the development of different Michael and Michael type
processes employing different bifunctional organocatalysts. All the processes studied
involved a non-covalent activation of the substrates ...
New techniques of molecular modelling and structural chemistry for the development of bioactive compounds
(2013-05-14)
Computational chemistry represents today a valid and fast tool for the research of new compounds with potential biological activity. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding ...
Congegni Supramolecolari basati sul Threading di Calixareni
(2013-02-01)
Recently, Neri et al have introduced an efficient method to obtain endo-cavity
complexation and through-the-annulus threading of large calixarenes exploiting the
inducing effect of a weakly coordinating anion, tetrakis ...
Synthesis, Structure and Properties of Cyclopeptoids and Cyclopeptides
(2014-01-29)
Aim of the research project has been the synthesis of cyclopeptides and cyclopeptoids in order to investigate their structural properties and catalytic activities.
In particular, studies of the arrangement and the cyclopeptoids ...
New chemical topologies based on calixarene threading
(2014-03-11)
Recently, Neri et al. have introduced an efficient method to obtain endo-cavity complexation and through-the-annulus threading of large calixarenes by exploiting the inducing effect of the weakly coordinating tetrakis[3, ...
Design, virtual screening and structural studies of new molecules with potential antitumor and antiinflammatory activity
(2012-03-30)
Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization.
The study ...
Total synthesis of terpenoidic unsatured dialdehydes and evaluation of their activity towards TRP receptors
(2012-02-02)
The aim of this PhD project has been to develop new synthetic strategies in
enantioselective preparation of natural products.
In particular my attention has been focused on preparation of some natural
metabolite, containing ...
A multi-disciplinary approach based on mass spectrometry to disclose the potential of phytoextracts as natural cosmetics
(2023-04-09)
Plant cells represent a valid source of cosmetic ingredients since their extracts can be considered bio-sustainable, contaminant-free and standardized secondary metabolites mixtures (Barbulova et al., 2014). This PhD project ...
Development of novel anticancer compounds directed towards promising therapeutic targets
(2023-04-19)
Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role
in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant
activity in proteins involved in this crucial ...
Asymmetric synthesis of Heterocyclic Compounds through cascade Carbon-Carbon and Carbon-Heteroatom bond forming processes
(2023-06-06)
The aim of my PhD thesis was focused on the asymmetric synthesis of new heterocyclic compounds using
cascade and tandem processes involving the formation of new binding Carbon-Carbon and Carbon-
Heteroatom.
Heterocyclic ...
New applications of Ester/Amide surrogates in organic synthesis
(2021-04-22)
Masked esters/amides are scaffolds endowed with a great potential in the field of organic synthesis. This PhD
project has been conceived, in the context of non-covalent organocatalysis, with the aim to exploit unsaturated ...
Chiral Bioactive Cyclopeptoids: Concepts and Purposes
(2020-02-09)
Peptides are an endless source of inspiration for medicinal chemistry, as these biomacromolecules regulate a number of biological activities, acting as hormones, neurotransmitters, signalling molecules and so on. They show ...
New perspectives in phase transfer catalysis
(2020-02-11)
The increasing demand for the stereoselective synthesis of bioactive compounds in both industrial and academic research has led to the rapid development of a variety of diastereo- and enantio-selective processes using phase ...
Targeted and untargeted proteomic approaches to disclose small molecules interactome
(2023-04-24)
The identification of natural products and synthetic compounds target proteins is pivotal to
understand their mechanism of action for the development of molecular probes and/or potential drugs.
Functional proteomics is a ...
Synthesis of Eco-Friendly Additives for Sustainable Tanning Processes
(2022-06-08)
Sustainability is a global level challenge for tanning industry whose
production is based on Cr(III) salts for more than 90%, negatively impacting
both biotic and abiotic factors in an ecosystem. Societal challenges ...