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Minimally invasive swine experimental model for the in vivo study of liver metabolism of drugs
(2012)
Purpose: To develop a clinically relevant
porcine model for the study of hepatic metabolism of drugs
by means of hepatic vein catheterization.
Materials and Methods: review of literature and
elaboration of a hypothesis, ...
Prognostic differences between VAP caused by Acinetobacter baumannii and VAP caused by other microorganisms
(2012)
Nosocomial infection, in particular pneumonia, is an important risk factor for hospital mortality and morbidity. Acinetobacter baumannii is a common multi-resistant microorganism responsible of Ventilator Associated Pneumonia ...
Perioperative anaphylactic risk score for risk-oriented premedication
(2013)
Basing on the current knowledge, this paper is aimed to review the core characteristics of the most relevant therapeutic agents (steroids and antihistamines), administered to prevent perioperative anaphylaxis. Moreover, ...
Vaptans and hyponatremia in critical patients
(2012)
Hyponatremia is the most frequent fluid and electrolyte disorder in hospitalized patients (20%), particularly in ICU, associated with an increase in morbility and mortality. While hypovolaemic hyponatremia needs to be ...
Aneurysmal subarachnoid haemorrhage in pregnancy: a case series
(2012)
Pregnancy is a recognized risk factor for aneurysmal subarachnoid hemorrhage (SAH). Headache is very frequent in normal pregnancy and it is a common sign shared between several intracranial diseases. We present a case ...
Dopamine use in intensive care: are we ready to turn it down?
(2012)
Dopamine is still frequently used as a first line
vasopressor agent in hypotensive patients, when physicians
are afraid of noradrenaline and believe that dopamine, with
its β and α, inotrope and vasopressor effects, may ...
Pharmacokinetics of remifentanil: a three-compartmental modeling approach
(2013)
Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics ...
Sepsis-associated encephalopathy
(2012)
Sepsis-associated encephalopathy (SAE) is defined as a diffuse or multifocal cerebral dysfunction induced by the systemic response to the infection without clinical or laboratory evidence of direct brain infection. Its ...
SiRNA delivery for control of cyclin d1 and e2f1 expression in crohn’s disease
(2017)
Evidence in inflammatory bowel diseases (IBD)
supports a connection between inflammation and cancer
due to the alteration of the cell cycle with loss of control
at the G1/S checkpoint. In this study, we analyze the
expression ...
Effect of α2-adrenergic agonists and antagonists on cytokine release from human lung macrophages cultured in vitro
(2016)
The most trusted hypothesis to explain
how α2-adrenergic agonists may preserve pulmonary
functions in critically ill patients is that they directly
act on macrophages by interfering with an
autocrine/paracrine adrenergic ...