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Adrenergic mechanism in the control of endothelial function
(2011)
There is considerable evidence that many disease are associated with endothelial dysfunction and reduced nitric oxide production such as hypertension, obesity, dyslipidemias, diabetes, heart failure, atherosclerosis. Notably ...
A polymorphism within the promoter of the dopamine receptor D1 (DRD1 -48A7G) associates with impaired kidney function in white hypertensive patients
(2012)
Dopamine DRD1 receptor regulates renal function and vascular resistance. It plays a role in the pathogenesis of hypertension in animal models. In humans, the DRD1 gene presents a A-48G polymorphism associated to hypertension ...
Redesigning Service Delivery for Hypertensive Patients: A Methodological Guideline to Improve the Management of Chronic Diseases
(2014)
Best care is not necessarily the most expensive, but the most appropriate, and prevention is the most powerful tool to promote health. A novel approach might envision the reduction of hospital admittance (thus meeting a ...
To NFkB or not to NFkB: the dilemma on how to inhibit a cancer cell fate regulator
(2012)
Nuclear factor B (NFB) is a transcription
factor that plays an important role in carcinogenesis as well
as in the regulation of inflammatory response. NFB is
constitutively expressed in tumours where it induces the ...
Dual role of grk5 in cancer development and progression
(2016)
GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the ...
Models for preclinical studies in aging-related disorders: one is not for all
(2015)
Preclinical studies are essentially based on animal models of a particular disease. The primary purpose of preclinical efficacy studies is to support generalization of treatment–effect relationships to human subjects. ...
Rays sting: the acute cellular effects of ionizing radiation exposure
(2016)
High-precision radiation therapy is a clinical approach that uses the targeted delivery of ionizing radiation, and the subsequent formation of reactive oxygen species (ROS) in high proliferative, radiation sensitive cancers. ...
Implementing an ict-based polypharmacy management program in Italy
(2017)
Although there is evidence of a growing
awareness of the problem, no official policy statements or
regulatory guidelines on polypharmacy have been released
up to date by Italian Health Authorities. Medication
review, ...
Larger blood pressure reduction by fixed-dose compared to free dose combination therapy of ace inhibitor and calcium antagonist in hypertensive patients
(2017)
The introduction of fixed combination of
ACEi+CCB (Fixed) has significantly increased patients
compliance and adherence to therapy. At the moment,
however, there are no data suggesting the better control of
once-daily fixed ...
Public prevention plans to manage climate change and respiratory allergic diseases. Innovative models used in Campania Region (Italy): the twinning Aria implementation and the allergy safe tree: decalogue
(2019)
In recent years, climate change has been
influenced by air pollution, and this destructive
combination has justifiably sounded an alarm for
nations and many institutional bodies worldwide.
Official reports state that the ...
The reference site collaborative network of the european innovation partnership on active and healthy ageing
(2019)
Seventy four Reference Sites of the European Innovation
Partnership on Active and Healthy Ageing (EIP on AHA)
have been recognised by the European Commission in
2016 for their commitment to excellence in investing and
scaling ...
An approach to prevent frailty in community dwelling older adults: a pilot study performed in Campania region in the framework of the PERSSILAA project
(2019)
We developed and tested an innovative physical
training method in older adults that embeds the gym
program into everyday life in the most conservative
way possible. Physical training was included in the
activities of local ...
Innovative approaches to active and healthy ageing: Campania experience to improve the adoption of innovative good practices
(2019)
The demographic projections on the
European population predict that people aged over
60 will increase by about two million/year in the next
decades. Since 2012, the Campania Reference Site of
the European Innovation ...
The european innovation partnership on active and healthy ageing synergies: protocol for a prospective observational study to measure the impact of a community-based program on prevention and mitigation of frailty (ICP –PMF) in community-dwelling older adults
(2016)
Aim of this paper is to describe the protocol of the
study “Impact of a Community-based Program on
Prevention and Mitigation of Frailty in communitydwelling older adults” developed in the framework of
the European Innovation ...