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Adrenergic mechanism in the control of endothelial function
(2011)
There is considerable evidence that many disease are associated with endothelial dysfunction and reduced nitric oxide production such as hypertension, obesity, dyslipidemias, diabetes, heart failure, atherosclerosis. Notably ...
A polymorphism within the promoter of the dopamine receptor D1 (DRD1 -48A7G) associates with impaired kidney function in white hypertensive patients
(2012)
Dopamine DRD1 receptor regulates renal function and vascular resistance. It plays a role in the pathogenesis of hypertension in animal models. In humans, the DRD1 gene presents a A-48G polymorphism associated to hypertension ...
To NFkB or not to NFkB: the dilemma on how to inhibit a cancer cell fate regulator
(2012)
Nuclear factor B (NFB) is a transcription
factor that plays an important role in carcinogenesis as well
as in the regulation of inflammatory response. NFB is
constitutively expressed in tumours where it induces ...
Redesigning Service Delivery for Hypertensive Patients: A Methodological Guideline to Improve the Management of Chronic Diseases
(2014)
Best care is not necessarily the most expensive, but the most appropriate, and prevention is the most powerful tool to promote health. A novel approach might envision the reduction of hospital admittance (thus meeting a ...
Models for preclinical studies in aging-related disorders: one is not for all
(2015)
Preclinical studies are essentially based on animal models of a particular disease. The primary purpose of preclinical efficacy studies is to support generalization of treatment–effect relationships to human subjects. ...
Rays sting: the acute cellular effects of ionizing radiation exposure
(2016)
High-precision radiation therapy is a clinical approach that uses the targeted delivery of ionizing radiation, and the subsequent formation of reactive oxygen species (ROS) in high proliferative, radiation sensitive cancers. ...
Dual role of grk5 in cancer development and progression
(2016)
GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the ...