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Accelerated bone mass senescence after hematopoietic stem cell transplantation
(2013)
Osteoporosis and avascular necrosis
(AVN) are long-lasting and debilitating complications of hematopoietic stem cell transplantation
(HSCT).
We describe the magnitude of bone loss, AVN
and impairment in osteogenic ...
Molecular Pathogenesis of Myelodysplastic Syndromes
(2014)
Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders characterized by inefficient hematopoiesis, hypercellular bone marrow, dysplasia of blood cells and cytopenias. Most patients are diagnosed in ...
Immunological derangement in Hypocellular Myelodysplastic Syndromes
(2014)
Hypocellular or hypoplastic myelodysplastic syndromes (HMDS) are a distinct subgroup accounting for 10–15% of all MDS patients, that are characterized by the presence of bone marrow (BM) hypocellularity, various degree of ...
Clonal non-malignant hematological disorders: unraveling molecular pathogenic mechanisms to develop novel targeted therapeutics
(2014)
Clonal non-malignant hematological disorders are a heterogeneous group of diseases that are particularly challenging for hematologists. Indeed, most obvious and frequent hematological diseases include a broad spectrum of ...
OPSI threat in hematological patients
(2013)
Overwhelming post-splenectomy infection (OPSI) is a rare medical emergency, mainly caused by encapsulated bacteria, shortly progressing from a mild flu-like syndrome to a fulminant, potentially fatal, sepsis. The risk of ...
The urokinase/urokinase receptor system in mast cells: effects of its functional interaction with fmlf receptors
(2016)
Mast cell and basophils express the high
affinity receptor for IgE (FcRI) and are primary
effector cells of allergic disorders. The urokinase
(uPA)-mediated plasminogen activation system is
involved in physiological ...
Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer
(2016)
The urokinase (uPA)-type
plasminogen activator receptor (uPAR) is a GPIanchored receptor that focuses urokinase (uPA)
proteolytic activity on the cell surface. uPAR also
regulates cell adhesion, migration and ...
In vitro apoptotic effects of farnesyltransferase blockade in acute myeloid leukemia cells
(2016)
Farnesyltransferase inhibitors (FTIs)
are a class of oral anti-cancer drugs currently tested
in phase I-II clinical trials for treatment of
hematological malignancies. The in vitro effects of
various FTIs (alpha-hydr ...
67 kDa laminin receptor (67LR) in normal and neoplastic hematopoietic cells: is its targeting a feasible approach?
(2016)
The 67 kDa laminin receptor (67LR)
is a non-integrin cell surface receptor for laminin
(LM) that derives from a 37 kDa precursor (37LRP).
67LR expression is increased in neoplastic cells and
correlates with an enhanced ...
Prolonged complete hematologic response in relapsed/refractory T-large granular lymphocyte leukemia after bendamustine treatment
(2016)
T-large granular lymphocyte
leukemia (T-LGLL) is a chronic clonal proliferation
of effector memory cytotoxic CD3+CD57+CD56- T
cells and the current guidelines suggest
immunosuppressive therapy as first-line therapy, ...
Mean reticolocyte hemoglobin content index plays a key role to identify children who are carriers of β –thalassemia
(2017)
Reticulocyte (r) and red blood cell
(RBC) indices provide reliable parameters for
screening and monitoring iron deficiency anemia
(IDA) patients and β-thalassemia trait (BTT)
carriers. The aim of this study is to ...