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Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products 

De Simone, Rosa (2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...
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Synthesis and properties of linear and cyclic peptoids 

De Cola, Chiara (2012-03-26)
Le strutture e le attività metaboliche di tutte le cellule si basano su una vasta gamma di molecole comprendenti: amminoacidi, carboidrati, lipidi e nucleotidi, insieme alle forme polimeriche di questi composti. Ognuna di ...
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Design e sintesi di analoghi delle azumammidi, potenti inibitori degli enzimi HDACs 

Cafaro, Emiddio (2011-03-07)
Le azumammidi sono cinque ciclopeptidi di origine marina, isolate nel 2003 da Fusetani et al dalla spugna Mycale izuensis e brevettate dalla Yamanouchi Pharmaceutical. L'interesse destato da questi metaboliti secondari è ...
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Chemical proteomics on ligand protein 

Margarucci, Luigi (2011-03-18)
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ...
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Enzymatic synthesis of macrolactones 

Fortunati, Tancredi (2011-02-24)
Macrolactones are a large and structurally diverse class of compounds. Natural products having a macrolactone structure have been isolated from many natural sources such as plants, insects, marine organism and bacteria. ...
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Stereoselective carbon-carbon and carbon-heteroatom bond formation mediated by bifunctional organocatalysts 

De Fusco, Claudia (2013-01-30)
This PhD work describes the development of different Michael and Michael type processes employing different bifunctional organocatalysts. All the processes studied involved a non-covalent activation of the substrates ...
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New techniques of molecular modelling and structural chemistry for the development of bioactive compounds 

Lauro, Gianluigi (2013-05-14)
Computational chemistry represents today a valid and fast tool for the research of new compounds with potential biological activity. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding ...
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Congegni Supramolecolari basati sul Threading di Calixareni 

Talotta, Carmen (2013-02-01)
Recently, Neri et al have introduced an efficient method to obtain endo-cavity complexation and through-the-annulus threading of large calixarenes exploiting the inducing effect of a weakly coordinating anion, tetrakis ...
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Synthesis, Structure and Properties of Cyclopeptoids and Cyclopeptides 

Nardone, Brunello (2014-01-29)
Aim of the research project has been the synthesis of cyclopeptides and cyclopeptoids in order to investigate their structural properties and catalytic activities. In particular, studies of the arrangement and the cyclopeptoids ...
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New chemical topologies based on calixarene threading 

Ciao, Roberta (2014-03-11)
Recently, Neri et al. have introduced an efficient method to obtain endo-cavity complexation and through-the-annulus threading of large calixarenes by exploiting the inducing effect of the weakly coordinating tetrakis[3, ...
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Design and structural optimization of new molecules as potential antiinflammatory and/or anticancer agents. 

Strocchia, Maria (2015-03-10)
L’infiammazione ed il cancro sono due complessi meccanismi patologici in cui risultano coinvolti una serie di differenti mediatori molecolari. La profonda connessione tra cancro ed infiammazione è ben nota e la modulazione ...
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Design, virtual screening and structural studies of new molecules with potential antitumor and antiinflammatory activity 

Chini, Maria Giovanna (2012-03-30)
Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization. The study ...
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Total synthesis of terpenoidic unsatured dialdehydes and evaluation of their activity towards TRP receptors 

D'Acunto, Mariantonietta (2012-02-02)
The aim of this PhD project has been to develop new synthetic strategies in enantioselective preparation of natural products. In particular my attention has been focused on preparation of some natural metabolite, containing ...
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New insights into peptoids' chemistry: synthesis, characterization and properties 

Meli, Alessandra (2016-05-11)
My PhD research activity aimed to enrich the realm of peptoids1 with novel compounds and new insights into their behavior and properties, investigating their potential applications. A new class of cyclic “arylopeptoids” ...
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Chiral organocatalysts mediated asymmetric oxyfunctionalization and tandem reaction 

Meninno, Sara (2015-03-13)
Asymmetric organocatalysis is a new rapidly growing field whose huge potential is becoming more and more evident.This PhD project has been conceived and developed in the context of non-covalent organocatalysis. The aim of ...
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Development of new in vitro models based on the use of electrospun scaffolds and their imaging by multiphoton microscopy coupled with fluorescence lifetime imaging microscopy 

Piccirillo, Germano Pasquale (2018-02-22)
In this thesis, new possible applications of electrospun scaffolds are presented. Besides, the interaction of human dermal fibroblasts (HDFs) with the materials has been investigated using multiphoton microscopy (MPM) ...
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Innovative applications of stable carbon isotope ratio in environmental and food chemistry 

Pironti, Concetta (2018-03-08)
In the last year, the stable isotope ratio analysis has become a useful tool with many applications in different scientific area. In particular the characteristic isotope signature of materials has permitted to identify ...
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Supramolecular Scaffolds for Biomimetic Catalysis 

La Manna, Pellegrino (2018-03-02)
This PhD thesis is concerned with the design, synthesis and the characterization of supramolecular scaffolds for biomimetic catalysis. Development of new organocatalytic systems based upon well-designed calix[4]arene ...
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Structural studies, design, identification and biological evaluation of bioactive compounds settore 

Cantone, Vincenza (2016-04-04)
Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ...
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Cavity Filling and Chirality Effects in Calixarene Threading 

Concilio, Gerardo (2016-03-16)
In 2010, the Prof. Neri’s group showed that the calix[6]arene hosts were able to recognize dialkylammonium axles when they were coupled with the weakly coordinating Tetrakis[3,5 bis(triFluoromethyl)Phenyl]Borate (TFPB−) ...
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AuthorCafaro, Emiddio (1)Cantone, Vincenza (1)Capaccio, Vito (1)Cassiano, Chiara (1)Chini, Maria Giovanna (1)Ciao, Roberta (1)Concilio, Gerardo (1)D'Acunto, Mariantonietta (1)De Cola, Chiara (1)De Fusco, Claudia (1)... View MoreSubject
CHIM/06 CHIMICA ORGANICA (29)
Calixareni (2)Mass spectrometry (2)mPGES-1 (2)Organocatalysis (2)Antitumoral (1)Azumammidi (1)BAG3 (1)Bioactive small molecules (1)Butyrolactones (1)... View MoreDate Issued2018 (5)2019 (5)2011 (4)2012 (3)2013 (3)2014 (3)2016 (3)2015 (2)2017 (1)Has File(s)
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EleA themes by Ugsiba