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Supramolecular Scaffolds for Biomimetic Catalysis
(Universita degli studi di Salerno, 2018-03-02)
This PhD thesis is concerned with the design, synthesis and the characterization of supramolecular scaffolds for biomimetic catalysis. Development of new organocatalytic systems based upon well-designed calix[4]arene ...
Development of new in vitro models based on the use of electrospun scaffolds and their imaging by multiphoton microscopy coupled with fluorescence lifetime imaging microscopy
(Universita degli studi di Salerno, 2018-02-22)
In this thesis, new possible applications of electrospun scaffolds are presented. Besides, the interaction of human dermal fibroblasts (HDFs) with the materials has been investigated using multiphoton microscopy (MPM) ...
Innovative applications of stable carbon isotope ratio in environmental and food chemistry
(Universita degli studi di Salerno, 2018-03-08)
In the last year, the stable isotope ratio analysis has become a useful tool with many applications in different scientific area. In particular the characteristic isotope signature of materials has permitted to identify ...
Calixarene based catalytic systems
(Universita degli studi di Salerno, 2018-02-22)
Catalysis is the essence of chemistry as it provides useful tools to make and brake chemical bonds. As nature has been a guide to many scientists, it’s no surprise that in the field of catalysis enzymes were a source of ...
Novel macrocyclic systems in asymmetric phase-transfer catalysis
(Universita degli studi di Salerno, 2017-02-27)
In the great realm of organic synthesis, phase-transfer catalysis (PTC) is a well recognized methodology which plays a key role both in industry and academia research. This process involves reactions that take place between ...
Synthesis and properties of linear and cyclic peptoids
(Universita degli studi di Salerno, 2012-03-26)
Le strutture e le attività metaboliche di tutte le cellule si basano su una vasta gamma di molecole comprendenti: amminoacidi, carboidrati, lipidi e nucleotidi, insieme alle forme polimeriche di questi composti. Ognuna di ...
Enzymatic synthesis of macrolactones
(Universita degli studi di Salerno, 2011-02-24)
Macrolactones are a large and structurally diverse class of compounds. Natural products having a
macrolactone structure have been isolated from many natural sources such as plants, insects,
marine organism and bacteria. ...
Design e sintesi di analoghi delle azumammidi, potenti inibitori degli enzimi HDACs
(Universita degli studi di Salerno, 2011-03-07)
Le azumammidi sono cinque ciclopeptidi di origine marina, isolate nel 2003 da
Fusetani et al dalla spugna Mycale izuensis e brevettate dalla Yamanouchi Pharmaceutical.
L'interesse destato da questi metaboliti secondari ...
Chemical proteomics on ligand protein
(Universita degli studi di Salerno, 2011-03-18)
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ...
Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(Universita degli studi di Salerno, 2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...
New techniques of molecular modelling and structural chemistry for the development of bioactive compounds
(Universita degli studi di Salerno, 2013-05-14)
Computational chemistry represents today a valid and fast tool for the research of new compounds with potential biological activity. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding ...
Stereoselective carbon-carbon and carbon-heteroatom bond formation mediated by bifunctional organocatalysts
(Universita degli studi di Salerno, 2013-01-30)
This PhD work describes the development of different Michael and Michael type processes employing different bifunctional organocatalysts. All the processes studied involved a non-covalent activation of the substrates ...
Congegni Supramolecolari basati sul Threading di Calixareni
(Universita degli studi di Salerno, 2013-02-01)
Recently, Neri et al have introduced an efficient method to obtain endo-cavity
complexation and through-the-annulus threading of large calixarenes exploiting the
inducing effect of a weakly coordinating anion, tetrakis ...
Synthesis, Structure and Properties of Cyclopeptoids and Cyclopeptides
(Universita degli studi di Salerno, 2014-01-29)
Aim of the research project has been the synthesis of cyclopeptides and cyclopeptoids in order to investigate their structural properties and catalytic activities.
In particular, studies of the arrangement and the ...
Design and structural optimization of new molecules as potential antiinflammatory and/or anticancer agents.
(Universita degli studi di Salerno, 2015-03-10)
L’infiammazione ed il cancro sono due complessi meccanismi patologici in cui risultano coinvolti una serie di differenti mediatori molecolari. La profonda connessione tra cancro ed infiammazione è ben nota e la modulazione ...
New insights into peptoids' chemistry: synthesis, characterization and properties
(Universita degli studi di Salerno, 2016-05-11)
My PhD research activity aimed to enrich the realm of peptoids1 with novel compounds and new insights into their behavior and properties, investigating their potential applications.
A new class of cyclic “arylopeptoids” ...
Structural studies, design, identification and biological evaluation of bioactive compounds settore
(Universita degli studi di Salerno, 2016-04-04)
Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ...
Cavity Filling and Chirality Effects in Calixarene Threading
(Universita degli studi di Salerno, 2016-03-16)
In 2010, the Prof. Neri’s group showed that the calix[6]arene hosts were able to recognize dialkylammonium axles when they were coupled with the weakly coordinating Tetrakis[3,5 bis(triFluoromethyl)Phenyl]Borate (TFPB−) ...
New chemical topologies based on calixarene threading
(Universita degli studi di Salerno, 2014-03-11)
Recently, Neri et al. have introduced an efficient method to obtain endo-cavity complexation and through-the-annulus threading of large calixarenes by exploiting the inducing effect of the weakly coordinating tetrakis[3, ...
Total synthesis of terpenoidic unsatured dialdehydes and evaluation of their activity towards TRP receptors
(Universita degli studi di Salerno, 2012-02-02)
The aim of this PhD project has been to develop new synthetic strategies in
enantioselective preparation of natural products.
In particular my attention has been focused on preparation of some natural
metabolite, ...