Translational Medicine @ UniSa. Vol.8 (jan.-mar. 2014)
<b>INDEX</b> <li>1. A. M. Risitano, C. Selleri CLONAL NON-MALIGNANT HEMATOLOGICAL DISORDERS: UNRAVELING MOLECULAR PATHOGENIC MECHANISMS TO DEVELOP NOVEL TARGETED THERAPEUTICS. (1-3) <li>2. R. Zambello, A. Teramo, C. Gattazzo, G. Semenzato ARE T-LGL LEUKEMIA AND NK-CHRONIC LYMPHOPROLIFERATIVE DISORDER REALLY TWO DISTINCT DISEASES? (4-11) <li>3. C. Palladino, B. Bruno, M. Boccadoro DISCOVERING THE MEANING OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: CURRENT KNOWLEDGE, FUTURE CHALLENGES. (12-18) <li>4. V. Visconte, C. Selleri, J. P. Maciejewski, R. V. Tiu MOLECULAR PATHOGENESIS OF MYELODYSPLASTIC SYNDROMES. (19-30) <li>5. B Serio, AM Risitano, V Giudice, N Montuori, C Selleri IMMUNOLOGICAL DERANGEMENT IN HYPOCELLULAR MYELODYSPLASTIC SYNDROMES. (31-42) <li>6. A. M Risitano ANTI-COMPLEMENT TREATMENT IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: WHERE WE STAND AND WHERE WE ARE GOING. (43-52) <li>7. A. Tabarroki, R. V. Tiu MOLECULAR GENETICS OF MYELOFIBROSIS AND ITS ASSOCIATED DISEASE PHENOTYPES. (53-64) <li>8. D. Magliacane, R. Parente, M. Triggiani CURRENT CONCEPTS ON DIAGNOSIS AND TREATMENT OF MASTOCYTOSIS. (65-74) <li>9. G. D’Arena, P. Musto MONOCLONAL B-CELL LYMPHOCYTOSIS. (75-79) <li>10. ERRATA CORRIGE
Immissioni Recenti
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Discovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challenges
(2014)Monoclonal gammopathy of undetermined significance (MGUS) is a non malignant plasma cell disorder with a relatively low risk of progression to Multiple Myeloma (MM) and to related Plasma cells disordes (lymphoplasmacellular ... -
Are T-LGL leukemia and NK-chronic lymphoproliferative disorder really two distinct diseases?
(2014)Mature Large Granular lymphocytes (LGL) disorders include a spectrum of conditions, ranging from polyclonal to clonal indolent and/or overt leukemic LGL proliferations. Most cases are represented by clonal expansions of ... -
Clonal non-malignant hematological disorders: unraveling molecular pathogenic mechanisms to develop novel targeted therapeutics
(2014)Clonal non-malignant hematological disorders are a heterogeneous group of diseases that are particularly challenging for hematologists. Indeed, most obvious and frequent hematological diseases include a broad spectrum of ... -
Errata corrige
(2014) -
Monoclonal B-cell lymphocytosis
(2014)Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 109/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, ... -
Current Concepts on Diagnosis and Treatment of Mastocytosis
(2014)Mastocytosis is a heterogeneous group of disorders characterized by a clonal proliferation and accumulation of mast cells in one or more organ, primarily in the skin and bone marrow. The clinical spectrum of the disease ... -
Molecular Genetics of Myelofibrosis and its associated Disease Phenotypes
(2014)In 2005, the discovery of Janus kinase 2 (JAK2) V617F mutation in approximately half of patients with myelofibrosis (MF) marked an important milestone in our understanding of the pathophysiology of MF. This has broadened ... -
Anti-complement treatment in paroxysmal nocturnal hemoglobinuria: where we stand and where we are going
(2014)Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal, non-malignant, hematological disorder characterized by the expansion of hematopoietic stem cells and progeny mature blood cells which are deficient in some surface ... -
Immunological derangement in Hypocellular Myelodysplastic Syndromes
(2014)Hypocellular or hypoplastic myelodysplastic syndromes (HMDS) are a distinct subgroup accounting for 10–15% of all MDS patients, that are characterized by the presence of bone marrow (BM) hypocellularity, various degree of ... -
Molecular Pathogenesis of Myelodysplastic Syndromes
(2014)Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders characterized by inefficient hematopoiesis, hypercellular bone marrow, dysplasia of blood cells and cytopenias. Most patients are diagnosed in ...
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