Sfoglia Scienze del farmaco per Data di Pubblicazione
Items 21-34 di 34
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Innovative technological strategies for the production of in situ gelling powders containing active biomolecules for wound healing
(Universita degli studi di Salerno, 2022-05-02)The aim of this Ph.D. project is the development of novel topical formulations for the treatment of various wounds by innovative technologies (micro and nano spray drying). The specific objective is the production of a dry ... -
Design and synthesis of small molecules as ion channel modulators
(Universita degli studi di Salerno, 2022-05-02)My PhD research plan relates the exploration of the structural requirements for ionic channels modulation such as TRPM8 and Kv7 receptors. About the first field, we prepared a series of tryptophan-based derivatives of our ... -
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(Universita degli studi di Salerno, 2022-05-03)La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La metilazione dell'arginina ... -
Development of Innovative Agents for the Treatment of Metabolic Diseases
(Universita degli studi di Salerno, 2022-05-10)Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the leading cause of death in the world. To date three main therapeutic strategies have been evaluated to reduce circulating LDL-C ... -
Alginate hydrogels in drug delivery: from physico- chemical to technological studies of a promising polysaccharide for 3D printing applications.
(Universita degli studi di Salerno, 2022-10-20)Focusing the attention on the futuristic concept of personalized medicine, the Ph.D. project aimed to demonstrate the potentialities of hydrogels as a versatile feed material for the semi solid extrusion 3D printing process ... -
Effects of natural iron chelators on dendritic cells: anti-inflammatory activity, phenotypic characterization, and metabolomic analysis
(Universita degli studi di Salerno, 2022-12-16)Dendritic cells (DCs) are key regulators of the immune system that patrol all the compartments of the body. When exposed to danger signals, DCs mature, migrate to the draining lymph nodes, and activate the adaptive ... -
Role of H3K56 acetylation in Candida albicans virulence
(Universita degli studi di Salerno, 2022-12-20)Candida spp., especially Candida albicans, represent the third most frequent cause of infection in Intensive Care Units worldwide, with a mortality rate approaching 40%. The increasing antifungal resistance drastically ... -
Analytical procedures for the safety assessment of dietary supplements and botanicals
(Universita degli studi di Salerno, 2023-04-06)The consumption of dietary supplements and botanicals is not always safe and free of potential health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a group of plant secondary ... -
Proteomic investigation of the impact of Cannabidiolic acid on Eukaryotic Translation complex in glioblastoma
(Universita degli studi di Salerno, 2023-04-12)Phytocannabinoids, the major secondary metabolites of cannabis plants, exert a wide range of biological activities. The present work was focused on investigating the mechanism of action of cannabidiolic acid (CBDA) in U87MG ... -
Bioprospecting of plants from Campania region to promote the sustainable use of biodiversity
(Universita degli studi di Salerno, 2023-04-12)This research aimed to chemical-biological study of plant and fungal species from inland areas of Campania Region, typically used in preparations for medicinal purposes or food traditional recipes. In the preliminary part ... -
Design, synthesis and pharmacological evaluation of new enzyme inhibitors
(Universita degli studi di Salerno, 2023-04-13)My PhD research plan relates to the exploration of the structural requirements for the modulation of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part of my doctoral project ... -
Molecular mechanisms of TFF1-Helicobacter cross-talk
(Universita degli studi di Salerno, 2023-04-18)Helicobacter pylori is one of the most important pathogenic bacteria associated with various gastric diseases, including cancer. This pathogen induces an acute mucosal inflammatory response and, if not eradicated, it could ... -
Development of novel anticancer compounds directed towards promising therapeutic targets
(Universita degli studi di Salerno, 2023-04-19)Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant activity in proteins involved in this crucial ... -
Targeted and untargeted proteomic approaches to disclose small molecules interactome
(Universita degli studi di Salerno, 2023-04-24)The identification of natural products and synthetic compounds target proteins is pivotal to understand their mechanism of action for the development of molecular probes and/or potential drugs. Functional proteomics is a ...
