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Computational design of new antimicrobial peptides
(2018-04-13)
Antimicrobial peptides (AMP) are evolutionarily conserved components of the
innate immune system. They have a broad spectrum of action against bacteria,
fungi and viruses. Therefore, AMP are studied as probable substitutes ...
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(2018-04-20)
Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...
Molecular basis of cardiomiopathy
(2018-04-05)
The normal heart rhythm is guaranteed by an important
intercellular junctions system, named Gap Junction (GJs). Each
GJs consists of two units called connexons formed by six
specific trans-membrane proteins named connexins ...
Design, synthesis and biological activity of new target selective antitumoral agents
(2018-04-05)
Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ...
Drug delivery to the lung in Cystic Fibrosis: deposition, dissolution, mucus interaction and microbiological evaluation of dry powder inhalers
(2018-04-05)
The inhalation therapy consists of a direct administration of drugs for the treatment of lung
diseases. A formulation for inhalation is a valid option in the symptomatic management of
pulmonary diseases typical of cystic ...